Venlafaxine hydrochloride

Drug ingredient

CAS 99300-78-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 99300-78-4
1 HCl
US productionNot reported
Import value, 2024$652M
Top sourceSingapore 77%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292250 · basket

These shares come from HS customs code 292250, which covers 76 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 77%SingaporeCN 12%ChinaIT 4%ItalyIN 2%IndiaGB 1%United Kingdom
74 FDA-registered drug labelers
A-S Medication Solutions
Aarti Pharmalabs Limited
Advagen Pharma Ltd.
Advanced Rx of Tennessee, LLC
Advanced Rx Pharmacy of Tennessee, LLC
Ajanta Pharma USA Inc.
Alembic Pharmaceuticals Inc.
Alembic Pharmaceuticals Limited
American Health Packaging
Amoli Organics (A Division of Umedica Laboratories Pvt.Ltd.)
Annora Pharma Private Limited
Aphena Pharma Solutions - Tennessee, LLC
Ascend Laboratories, LLC
Asclemed USA, Inc.
Assia Chemical Industries Ltd - Teva Tech Site
Aurobindo Pharma Limited
AURORE PHARMACEUTICALS PRIVATE LIMITED
AvKARE
AvPAK
BluePoint Laboratories
Bryant Ranch Prepack
Cadila Pharmaceuticals Limited
Camber Pharmaceuticals, Inc.
Cardinal Health 107, LLC
Chartwell RX, LLC
Chongqing Carelife Pharmaceutical Co., Ltd.
Coupler LLC
Direct_Rx
Divi's Laboratories Limited
Dr. Reddy's Laboratories Inc.
Dr. Reddy's Laboratories Limited
Dr.Reddy's Laboratories Ltd.
Edenbridge Pharmaceuticals LLC.
Epic Pharma, LLC
Golden State Medical Supply, Inc.
Granules Pharmaceuticals Inc.
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Hetero Drugs Limited
HIKAL LIMITED
Ipca Laboratories Limited
Macleods Pharmaceuticals Limited
Major Pharmaceuticals
Marlex Pharmaceuticals, Inc.
Modavar Pharmaceuticals LLC
Moehs Cantabra S.L
MSN Life Sciences Private Limited
NCS HealthCare of KY, LLC dba Vangard Labs
Nivagen Pharmaceuticals, Inc.
Northwind Health Company, LLC
NuCare Pharmaceuticals Inc.
PD-Rx Pharmaceuticals, Inc.
Pfizer Ireland Pharmaceuticals Unlimited Company
Preferred Pharmaceuticals Inc.
Proficient Rx LP
QPharma, Inc.
QUALLENT PHARMACEUTICALS HEALTH LLC
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Siegfried AG
ST. MARY'S MEDICAL PARK PHARMACY
SUN PHARMACEUTICAL INDUSTRIES, INC.
Teva Pharmaceuticals USA, Inc.
Trigen Laboratories, LLC
UQUIFA Mexico, S.A. DE C.V.
Vertical Pharmaceuticals, LLC
Viatris Specialty LLC
Westminster Pharmaceuticals, LLC
Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.
XLCare Pharmaceuticals, Inc.
Yaopharma Co., Ltd.
Zhejiang Apeloa Jiayuan Pharmaceutical Co., Ltd.
zhejiang jiuzhou pharmaceutical Co., Ltd.
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

  • •Venlafaxine
  • •venlafaxine hydrochloride
  • •Effexor XR
  • •Venlafaxine HCL ER
  • •venlafaxine hydrochloride, extended release
  • •Venlafaxine hydrochloride ER
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.72/gCombi-Blocks, Inc.
CountryUnited States
Pack$360.00 / 500 g
Purity98%
Vendors24 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS99300-78-4
PubChem CID62923
DTXSIDDTXSID8047397
FormulaC17H28ClNO2
Mol. Weight313.9 g/mol
SMILESCN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl

Data Sources

Brief citations

Venlafaxine hydrochloride (CAS 99300-78-4) https://chemicalindependence.com/chemical/99300-78-4/ PubChem: 62923. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/62923 FDA National Drug Code directory: CAS 99300-78-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292250 for CAS 99300-78-4. Reporting year: 2024. https://usatrade.census.gov/