4-Hydroxyacetophenone

Drug ingredient

CAS 99-93-4

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$85M

Top sourceChina 53%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291450 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291450, which covers 68 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 53%ChinaIN 25%IndiaMX 9%MexicoDE 7%GermanyIT 4%Italy

Switzerland
Taiwan
South Korea
Canada
United Kingdom
Ukraine
Hong Kong
Romania
Austria
Spain
Lithuania

EPA-registered manufacturers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Basf

Domestic parents -- activity not disclosed (2)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Connect Chemicals Usa

Hydrite Chemical

Why It Matters

Sectors

HealthMetals & MiningCore Chemicals

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Barubt Ultimate Moisturizing Cream
•Anubis Barcelona Spa Line

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Antioxidant in Other (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.02/gAaron Chemicals LLC

CountryHong Kong

Pack$524.00 / 25 kg

Purity99%

Vendors37 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

36 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.03	500 g	98%
A2B Chem LLC	United States	$0.04	1 kg	98%
AA BLOCKS	United States	$0.04	500 g	98%
BLD Pharmatech GmbH	Germany	$0.05	1 kg	98%
BLD Pharmatech Ltd.	China	$0.05	1 kg	98%
Chemscene	United States	$0.05	1 kg	—
Fluorochem UK	United Kingdom	$0.07	500 g	97%
Angene International Limited	United States	$0.08	500 g	99%
Apollo Scientific UK	United Kingdom	$0.10	25 kg	99%
BLD Pharmatech Co., Limited	United States	$0.11	1 kg	98%
Ambeed, Inc.	United States	$0.11	1 kg	98%
Synthonix	United States	$0.16	500 g	95%
Fluorochem EU	Germany	$0.19	1 kg	97%
AK Scientific Specialized	United States	$0.23	1 kg	95%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
ALFA AESAR	Germany	$0.28	1 kg	99%
AK Scientific, Inc.	United States	$0.33	1 kg	98%
Sigma-Aldrich (Rush Stock)	Germany	$0.55	500 g	99%
Sigma-Aldrich	Germany	$0.55	500 g	99%
Cayman Europe	Estonia	$0.65	250 g	98%
AstaTech (2 weeks)	United States	$0.88	25 g	95%
Aldlab	United States	$1.38	10 g	95%
Interbioscreen	Hong Kong	$24.00	10 g	95%
Molnova	China	$74.00	500 mg	99%
TargetMol Chemicals	China → United States	$82.00	500 mg	99.98%
MedChemExpress MCE	Sweden	$125.84	500 mg	99.99%
Specs	Netherlands	$132.13	10 g	90%
ChemNorm	China	$150.00	100 mg	98%
Labotest KG	Germany	$217.80	5000 mg	90%
ChemFaces	China	$1500.00	20 mg	98%
Otava, Ltd.	Ukraine	$2280.00	50 mg	90%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	90%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%
Vitas M Chemical Limited	Hong Kong	$3170.00	100 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	98%
AnalytiCon Discovery - a Division of BRAIN Biotech AG	Germany	$111320.00	11 mg	85%

Chemical Identity

CAS99-93-4

PubChem CID7469

DTXSIDDTXSID0029133

FormulaC8H8O2

Mol. Weight136.15 g/mol

SMILESCC(=O)C1=CC=C(C=C1)O

Data Sources

EPA CompTox (DSSTox) · DTXSID0029133Retrieved 2026-04-06
PubChem · compound 7469Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

4-Hydroxyacetophenone (CAS 99-93-4) https://chemicalindependence.com/chemical/99-93-4/ EPA CompTox (DSSTox): DTXSID0029133. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID0029133 PubChem: 7469. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/7469 EPA Chemical Data Reporting: 99-93-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 99-93-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291450 for CAS 99-93-4. Reporting year: 2024. https://usatrade.census.gov/