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Valproic acid

Drug ingredient

CAS 99-66-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 99-66-1
US productionNot reported
Import value, 2024$384M
Top sourceMalaysia 21%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291590 · basket

These shares come from HS customs code 291590, which covers 588 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
MY 21%MalaysiaDE 13%GermanyNL 13%NetherlandsMX 10%MexicoIT 8%Italy
26 FDA-registered drug labelers
Actavis Pharma, Inc.
ANI Pharmaceuticals, Inc.
Anjan Drug Private Limited
Aphena Pharma Solutions - Tennessee, LLC
ATLANTIC BIOLOGICALS CORP.
B.V. KATWIJK CHEMIE
Bionpharma Inc.
Bryant Ranch Prepack
Catalent Pharma Solutions, LLC
Chartwell Governmental & Specialty RX, LLC.
Chartwell RX, LLC
Direct_Rx
Harman Finochem Limited
KALINTIS HEALTHCARE PRIVATE LIMITED
Kesin Pharma Corporation
NCS HealthCare of KY, LLC dba Vangard Labs
NorthStar Rx LLC
PAI Holdings, LLC dba PAI Pharma
Patheon Softgels Inc.
PCAS
QUAGEN PHARMACEUTICALS LLC
REMEDYREPACK INC.
SCI PHARMTECH, INC.
SUN PHARMACEUTICAL INDUSTRIES, INC.
Upsher-Smith Laboratories, LLC
Xttrium Laboratories Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Valproic
  • •Valproic Acid
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.12/gAaron Chemicals LLC
CountryHong Kong
Pack$116.00 / 1 kg
Purity98%
Vendors26 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

25 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.13500 g98%
AA BLOCKSUnited States$0.19500 g98%
A2B Chem LLCUnited States$0.19500 g98%
ChemsceneUnited States$0.271 kg—
Ambeed, Inc.United States$0.281 kg98%
Angene International LimitedUnited States$0.29500 g98%
AK Scientific SpecializedUnited States$0.46500 g97%
Fulfilled by MolportLatvia$0.5010 g97%
AK Scientific, Inc.United States$0.57500 g99%
Fluorochem UKUnited Kingdom$0.87100 g97%
AstaTech, IncUnited States$0.88100 g97%
Fluorochem EUGermany$0.9710 g97%
Cayman EuropeEstonia$2.24250 g95%
ALFA AESARGermany$2.4050 g98%
MedChemExpress MCESweden$4.0225 g99.72%
Apexbio Technology LLCUnited States$14.405 g98%
MedKoo Biosciences, IncUnited States$20.0010 g98%
MolnovaChina$45.001 g99%
TargetMol ChemicalsChina → United States$50.001 g99.49%
Sigma-Aldrich (Rush Stock)Germany$113.711 g—
Sigma-AldrichGermany$113.711 g—
Otava, Ltd. (2 weeks)Ukraine$2724.0050 mg90%
Life Chemicals Inc.Ukraine → Canada$3100.00100 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%
Key Organics Ltd.United Kingdom$6900.0010 mg99%

Chemical Identity

CAS99-66-1
PubChem CID3121
DTXSIDDTXSID6023733
FormulaC8H16O2
Mol. Weight144.21 g/mol
SMILESCCCC(CCC)C(=O)O

Data Sources

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Brief citations

Valproic acid (CAS 99-66-1) https://chemicalindependence.com/chemical/99-66-1/ PubChem: 3121. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3121 FDA National Drug Code directory: CAS 99-66-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291590 for CAS 99-66-1. Reporting year: 2024. https://usatrade.census.gov/