Ruxolitinib

Drug ingredient

CAS 941678-49-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 941678-49-5
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
5 FDA-registered drug labelers
Catalent Pharma Solutions, LLC
Chunghwa Chemical Synthesis & Biotech Co., Ltd.
Incyte Corporation
Patheon Manufacturing Services LLC
STERLING SPA

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Jakafi
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$96.00/gCombi-Blocks, Inc.
CountryUnited States
Pack$2400.00 / 25 g
Purity98%
Vendors25 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS941678-49-5
PubChem CID25126798
DTXSIDDTXSID10240930
FormulaC17H18N6
Mol. Weight306.4 g/mol
SMILESC1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

Data Sources

Brief citations

Ruxolitinib (CAS 941678-49-5) https://chemicalindependence.com/chemical/941678-49-5/ PubChem: 25126798. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/25126798 FDA National Drug Code directory: CAS 941678-49-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 941678-49-5. Reporting year: 2024. https://usatrade.census.gov/