Lumacaftor

Drug ingredient

CAS 936727-05-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

4 FDA-registered drug labelers

Aesica Queenborough Limited

Esteve Quimica SA

Maithri Drugs Private Limited

Vertex Pharmaceuticals Incorporated

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Orkambi

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$46.60/gCombi-Blocks, Inc.

CountryUnited States

Pack$1165.00 / 25 g

Purity98%

Vendors22 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

21 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$49.36	25 g	98%
AA BLOCKS	United States	$52.12	25 g	98%
Aaron Chemicals LLC	Hong Kong	$55.88	25 g	98%
BLD Pharmatech GmbH	Germany	$61.60	25 g	98%
BLD Pharmatech Ltd.	China	$61.60	25 g	98%
Angene Chemical	China → Hong Kong	$63.92	25 g	98%
AstaTech, Inc	United States	$67.00	5 g	97%
BLD Pharmatech Co., Limited	United States	$67.76	25 g	98%
Ambeed, Inc.	United States	$67.76	25 g	98%
AK Scientific Specialized	United States	$96.00	1 g	98%
Angene International Limited	United States	$117.00	5 g	98%
AK Scientific, Inc.	United States	$127.00	1 g	99%
MedKoo Biosciences, Inc	United States	$345.00	10 g	98%
Molnova	China	$564.00	500 mg	99%
TargetMol Chemicals	China → United States	$626.00	500 mg	99.72%
MedChemExpress MCE	Sweden	$999.46	500 mg	99.85%
ChemFaces	China	$1500.00	20 mg	98%
Apexbio Technology LLC	United States	$2660.00	50 mg	99.65%
Axon Medchem	Netherlands	$3600.00	50 mg	99%
Angene	China → Hong Kong	$4266.67	30 mg	98%
Cayman Europe	Estonia	$36176.00	25 mg	98%

Chemical Identity

CAS936727-05-8

PubChem CID16678941

DTXSIDDTXSID30239523

FormulaC24H18F2N2O5

Mol. Weight452.4 g/mol

SMILESCC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O

Data Sources

PubChem · compound 16678941Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

Lumacaftor (CAS 936727-05-8) https://chemicalindependence.com/chemical/936727-05-8/ PubChem: 16678941. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/16678941 FDA National Drug Code directory: CAS 936727-05-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 936727-05-8. Reporting year: 2024. https://usatrade.census.gov/