Ibrutinib

Drug ingredient

CAS 936563-96-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

16 FDA-registered drug labelers

Aarti Pharmalabs Limited

AbbVie Inc.

Assia Chemical Industries Ltd. - Teva Tech Site

Catalent Micron Technologies, Inc.

Catalent Pharma Solutions, LLC

Dr. Reddy's Laboratories Limited

Hetero Labs Limited

Lonza Guangzhou Pharmaceutical Ltd.

MSN Laboratories Private Limited

Natco Pharma Limited

Pharmacyclics LLC

ScinoPharm Taiwan Ltd.

Shanghai Huilun Jiangsu Pharmaceutical Co., Ltd.

SHILPA PHARMA LIFESCIENCES LIMITED

SUN PHARMACEUTICAL INDUSTRIES, INC.

Wavelength Enterprises LTD

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Imbruvica

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS936563-96-1

PubChem CID24821094

DTXSIDDTXSID60893450

FormulaC25H24N6O2

Mol. Weight440.5 g/mol

SMILESC=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N

Data Sources

PubChem · compound 24821094Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ibrutinib (CAS 936563-96-1) https://chemicalindependence.com/chemical/936563-96-1/ PubChem: 24821094. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/24821094 FDA National Drug Code directory: CAS 936563-96-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 936563-96-1. Reporting year: 2024. https://usatrade.census.gov/