Vemurafenib

Drug ingredient

CAS 918504-65-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$2.0B

Top sourceIreland 63%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293590 · basket

These shares come from HS customs code 293590, which covers 182 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 63%IrelandSG 14%SingaporeIN 7%IndiaCN 7%ChinaCH 2%Switzerland

Portugal
Spain
Italy
Austria
Israel
Hungary
Canada
South Korea
Netherlands
Finland
Poland
Indonesia
Ukraine
Mexico
South Africa
Croatia
Greece
Taiwan
Hong Kong

1 FDA-registered drug labeler

Genentech, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Zelboraf

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$74.10/gAngene Chemical

CountryChina (registered: Hong Kong)

Pack$741.00 / 10 g

Purity98%

Vendors22 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

21 more vendors

Vendor	Country	$/g	Pack	Purity
Aaron Chemicals LLC	Hong Kong	$78.00	5 g	98%
BLD Pharmatech Ltd.	China	$122.00	5 g	98%
Ambeed, Inc.	United States	$122.00	5 g	98%
AstaTech, Inc	United States	$171.80	5 g	98%
A2B Chem LLC	United States	$228.00	1 g	98%
AA BLOCKS	United States	$253.00	1 g	98%
BLD Pharmatech Co., Limited	United States	$320.00	1 g	98%
BLD Pharmatech GmbH	Germany	$320.00	1 g	98%
AK Scientific Specialized	United States	$320.00	1 g	95%
MedKoo Biosciences, Inc	United States	$330.00	5 g	98%
AK Scientific, Inc.	United States	$448.00	1 g	98%
Angene International Limited	United States	$478.00	1 g	95%
Molnova	China	$550.00	500 mg	99%
TargetMol Chemicals	China → United States	$612.00	500 mg	99.65%
Apexbio Technology LLC	United States	$880.00	500 mg	98.48%
MedChemExpress MCE	Sweden	$1125.30	500 mg	99.9%
ChemFaces	China	$1500.00	20 mg	98%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	95%
Axon Medchem	Netherlands	$5760.00	25 mg	98%
Cayman Europe	Estonia	$9448.60	50 mg	98%

Chemical Identity

CAS918504-65-1

PubChem CID42611257

DTXSIDDTXSID50238710

FormulaC23H18ClF2N3O3S

Mol. Weight489.9 g/mol

SMILESCCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F

Data Sources

PubChem · compound 42611257Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Vemurafenib (CAS 918504-65-1) https://chemicalindependence.com/chemical/918504-65-1/ PubChem: 42611257. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/42611257 FDA National Drug Code directory: CAS 918504-65-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293590 for CAS 918504-65-1. Reporting year: 2024. https://usatrade.census.gov/