Hyaluronic acid

Drug ingredient

CAS 9004-61-9

EPA’s 2019 records show zero U.S. production for this drug ingredient.

US productionZero

Import value, 2024$391M

Top sourceChina 23%

EPA lists this chemical for 2019 but publishes zero or no volume for both production and imports.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 391390 · basket

EPA reports by year

2019: US production Zero · Imports Zero

These shares come from HS customs code 391390, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 23%ChinaSE 22%SwedenAT 20%AustriaIT 10%ItalyJP 4%Japan

Netherlands
Bulgaria
Norway
Belgium
India
Lithuania
Brazil
Mexico
Malaysia
Dominican Republic
Colombia
Estonia
Taiwan
Barbados
Portugal
Ireland
Hong Kong
Vietnam
Poland
Finland
Hungary
Singapore

13 FDA-registered drug labelers

Beijing JUNGE Technology Co., Ltd.

BIOHERB Co., Ltd.

FlexiGo Inc

Guangdong Junhui Biotechnology Co., LTD

Guangzhou Kadiya Biotechnology Co., Ltd.

Guangzhou Meijiao Medical Biotechnology Co., Ltd.

Guangzhou Yanxi Biotechnology Co., Ltd

Guangzhou Yapeng Refinement Chemical Co., Ltd.

IDO PHARM

Jiangxi Yudexi Pharmaceutical Co., LTD

Piramal Pharma Solutions Inc.

Roushun Kojic Skin lightening natural skin care treatment serum

Shengnan (Guangzhou) Cosmetics Co., LTD

Why It Matters

Sectors

Health

Downstream Uses

Appears in 19 drug and cosmetic product listings (FDA).

•Massage cream
•AOAO Retinol Anti-aging Box Set
•Gaezoa Cream
•ClearSoothingCream
•Body essential oil
•Roushun kojic Skin Lightening Nutural Skin Care treament serum 30ml
•Gethorey Miracle BALM
•Jasbello Vaginal

Show all 19

•bodylotion
•Body oil
•EyeOne eyelid cleansing tools
•Feelshion Magnesium cream
•ANTI-Aging EYE MASK
•Instant Anti Aging Wrinkle Eye Treatment Syringe
•Menssoap
•Massage essential oil
•Dark Eye Anti Ageing Roller Pen
•Vitamin C Serum
•EyeOne Cleaner

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS9004-61-9

PubChem CIDNot recorded

DTXSIDDTXSID7046750

FormulaNot recorded

Mol. WeightNot recorded

SMILESNot recorded

Data Sources

EPA CompTox (DSSTox) · DTXSID7046750Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Hyaluronic acid (CAS 9004-61-9) https://chemicalindependence.com/chemical/9004-61-9/ EPA CompTox (DSSTox): DTXSID7046750. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7046750 EPA Chemical Data Reporting: 9004-61-9. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 9004-61-9. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 391390 for CAS 9004-61-9. Reporting year: 2024. https://usatrade.census.gov/