Papain

Drug ingredient

CAS 9001-73-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 9001-73-4
US productionNot reported
Import value, 2024$994M
Top sourceDenmark 25%

EPA lists this chemical for 2023 but publishes zero or no volume for both production and imports.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 350790 · basket

EPA reports by year
2023
US production Not published · Imports Not published

These shares come from HS customs code 350790, which covers 104 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
DK 25%DenmarkJP 11%JapanIT 10%ItalyDE 7%GermanyLT 7%Lithuania
Domestic parents -- activity not disclosed (1)
Brenntag
3 FDA-registered drug labelers
Energique, Inc.
Nutritional Specialties, Inc.
Professional Complementary Health Formulas

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Digestive Enzyme Liquescence 3007
  • •Metabatone
  • •Digestive Enzyme Liquescence
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS9001-73-4
PubChem CIDNot recorded
DTXSIDDTXSID7044184
FormulaNot recorded
Mol. WeightNot recorded
SMILESNot recorded

Data Sources

Brief citations

Papain (CAS 9001-73-4) https://chemicalindependence.com/chemical/9001-73-4/ EPA TSCA Inventory: CAS 9001-73-4. Retrieved 2026-04-29. https://www.epa.gov/tsca-inventory EPA Chemical Data Reporting: 9001-73-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 9001-73-4. Retrieved 2026-10-04. https://open.fda.gov/data/ndc/ US Census international trade: HS 350790 for CAS 9001-73-4. Reporting year: 2024. https://usatrade.census.gov/