Flag of the United StatesAmerican Chemical Independence

Gluconolactone

Drug ingredient

CAS 90-80-2

Companies reported imports and no US production of this drug ingredient to EPA for 2023.

Molecular structure of 90-80-2
US productionZero
Import value, 2024$286M
Import volume3.8M lb
Import dependency100%
Top sourceChina 48%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Gluconolactone · US import value by year
$292M2013$355M2019$286M2024$269M2025

2013: $292M · Peak 2019: $355M · 2024: $286M · 2025: $269M

Where It Comes From

Customs basis: HS 293220 · basket

EPA reports by year
2023
US production Zero · Imports 3.8M lb
2019
US production Zero · Imports 3.4M lb

These shares come from HS customs code 293220, which covers 151 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 48%ChinaIN 15%IndiaJP 7%JapanGB 7%United KingdomCH 7%Switzerland
EPA-registered importers (5)
Fuso Chemical · JP Japan
Jungbunzlauer Suisse Ag · CH Switzerland
Jungbunzlauer
Pmp Fermentation Products
Target
2 FDA-registered drug labelers
KRX RESOURCES SDN. BHD.
United-Guardian, Inc.

Why It Matters

Sectors
HealthConstructionConsumer ProductsCore Chemicals
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Renacidin
  • •Krx Aesthetics Biophase Molecular Night Peel
FDA Shortage Status
No FDA shortage records

Industrial Uses

Used in 2 sectors as 2 functional roles.

  • •Intermediate in All Other Basic Organic Chemical Manufacturing (20%)Processing—incorporation into formulation, mixture, or reaction product
  • •Chelating agent in Non-metallic Mineral Product Manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other non-metallic mineral product manufacturing) (1%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.01/gAaron Chemicals LLC
CountryHong Kong
Pack$7.00 / 500 g
Purity99%
Vendors31 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

30 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.02500 g99%
A2B Chem LLCUnited States$0.0225 kg98%
AA BLOCKSUnited States$0.0225 kg98%
BLD Pharmatech Ltd.China$0.031 kg98%
Ambeed, Inc.United States$0.031 kg98%
BLD Pharmatech GmbHGermany$0.031 kg98%
BLD Pharmatech Co., LimitedUnited States$0.05500 g98%
ChemsceneUnited States$0.051 kg—
Fluorochem EUGermany$0.061 kg98%
Sigma-Aldrich (Rush Stock)Germany$0.181 kg—
Sigma-AldrichGermany$0.181 kg—
MedChemExpress MCESweden$0.211 kg98%
AK Scientific SpecializedUnited States$0.22500 g98%
Combi-Blocks, Inc.United States$0.251 kg98%
Angene International LimitedUnited States$0.28100 g98%
AK Scientific, Inc.United States$0.30500 g98%
AstaTech (2 weeks)United States$9.50100 g95%
InterbioscreenHong Kong$64.5010 g95%
MolnovaChina$90.00500 mg99%
Vitas M Chemical LimitedHong Kong$390.00500 mg90%
Labotest KGGermany$453.001000 mg90%
AA BLOCKS (2 weeks)United States$962.005 g95%
A2B Chem LLC (2 weeks)United States$1022.605 g95%
A2B Chem LLC (1 week)United States$1776.00250 mg95%
Combi-Blocks (back-ordered)United States$2220.00250 mg95%
Princeton BioMolecular Research (SC)United States$2900.00100 mg90%
AngeneChina → Hong Kong$4266.6730 mg99%
Key Organics Ltd.United Kingdom$6900.0010 mg95%
TimTec, LLCUnited States$9333.3330 mg99%
AA BLOCKS (1 week)United States$20760.0025 mg—

Chemical Identity

CAS90-80-2
PubChem CID7027
DTXSIDDTXSID0026549
FormulaC6H10O6
Mol. Weight178.14 g/mol
SMILESC(C1C(C(C(C(=O)O1)O)O)O)O

Data Sources

← Back to Dashboard← Back to Health

Brief citations

Gluconolactone (CAS 90-80-2) https://chemicalindependence.com/chemical/90-80-2/ EPA CompTox (DSSTox): DTXSID0026549. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026549 PubChem: 7027. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/7027 EPA Chemical Data Reporting: 90-80-2. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 90-80-2. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293220 for CAS 90-80-2. Reporting year: 2024. https://usatrade.census.gov/