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Ivacaftor

Drug ingredient

CAS 873054-44-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 873054-44-5
US productionNot reported
Import value, 2024$111M
Top sourceIndia 28%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293349 · basket

These shares come from HS customs code 293349, which covers 94 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IN 28%IndiaCN 27%ChinaSE 12%SwedenKR 10%South KoreaGB 4%United Kingdom
18 FDA-registered drug labelers
Aesica Queenborough Limited
Alivus Life Sciences Limited
Aurobindo Pharma Limited
Biocon Limited
Catalent Pharma Solutions, LLC
HETERO LABS LIMITED
HOVIONE FARMACIENCIA S.A.
HOVIONE LIMITED
HOVIONE LLC
Maithri Drugs Private Limited
Medichem Manufacturing (Malta) Ltd.
Medichem S.A.
MSN Laboratories Private Limited
Patheon Pharmaceuticals Inc.
ScinoPharm Taiwan Ltd.
Shanghai SynTheAll Pharmaceutical Co., Ltd.
Vertex Pharmaceuticals Incorporated
Viyash Life Sciences Private Limited

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Orkambi
  • •Kalydeco
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$47.60/gBLD Pharmatech Ltd.
CountryChina
Pack$1190.00 / 25 g
Purity97%
Vendors25 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

24 more vendors
VendorCountry$/gPackPurity
A2B Chem LLCUnited States$48.405 g97%
Aaron Chemicals LLCHong Kong$49.1225 g98%
Angene ChemicalChina → Hong Kong$52.4825 g98%
AA BLOCKSUnited States$53.805 g97%
Combi-Blocks, Inc.United States$58.005 g98%
BLD Pharmatech Co., LimitedUnited States$68.005 g97%
BLD Pharmatech GmbHGermany$68.005 g97%
Ambeed, Inc.United States$68.005 g97%
AK Scientific SpecializedUnited States$99.001 g98%
AK Scientific, Inc.United States$132.001 g99%
Fluorochem UKUnited Kingdom$180.181 g98%
Angene International LimitedUnited States$188.001 g98%
AstaTech, IncUnited States$231.005 g95%
MedKoo Biosciences, IncUnited States$1475.002 g98%
Apexbio Technology LLCUnited States$1490.00100 mg98.18%
ChemFacesChina$1500.0020 mg98%
MolnovaChina$1890.00500 mg99%
AngeneChina → Hong Kong$2500.0030 mg98%
TargetMol ChemicalsChina → United States$3330.00200 mg99.98%
TargetMol Chemicals EUAustria$6380.0050 mg99.98%
MedChemExpress MCESweden$7005.90100 mg99.97%
Axon MedchemNetherlands$10200.0050 mg99%
Cayman EuropeEstonia$23157.4050 mg98%
Key Organics Ltd.United Kingdom$26900.0010 mg97%

Chemical Identity

CAS873054-44-5
PubChem CID16220172
DTXSIDDTXSID00236281
FormulaC24H28N2O3
Mol. Weight392.5 g/mol
SMILESCC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

Data Sources

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Brief citations

Ivacaftor (CAS 873054-44-5) https://chemicalindependence.com/chemical/873054-44-5/ PubChem: 16220172. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/16220172 FDA National Drug Code directory: CAS 873054-44-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293349 for CAS 873054-44-5. Reporting year: 2024. https://usatrade.census.gov/