trametinib

Drug ingredient

CAS 871700-17-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

4 FDA-registered drug labelers

Aurobindo Pharma Limited

AX Pharmaceutical Corp

Glaxo Wellcome Manufacturing Pte. Ltd

MSN Laboratories Private Limited

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$168.00/gCombi-Blocks, Inc.

CountryUnited States

Pack$1680.00 / 10 g

Purity98%

Vendors14 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

13 more vendors

Vendor	Country	$/g	Pack	Purity
Ambeed, Inc.	United States	$210.00	5 g	98%
AK Scientific Specialized	United States	$370.00	1 g	98%
AK Scientific, Inc.	United States	$496.00	1 g	99%
AstaTech, Inc	United States	$576.00	250 mg	95%
Molnova	China	$635.00	200 mg	99%
TargetMol Chemicals	China → United States	$705.00	200 mg	99.96%
Apexbio Technology LLC	United States	$884.00	500 mg	99.33%
MedChemExpress MCE	Sweden	$1074.48	500 mg	99.93%
MedKoo Biosciences, Inc	United States	$1475.00	2 g	98%
Cayman Europe	Estonia	$1908.76	250 mg	95%
ChemFaces	China	$2000.00	20 mg	98%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	99%
Axon Medchem	Netherlands	$9600.00	25 mg	99%

Chemical Identity

CAS871700-17-3

PubChem CID11707110

DTXSIDDTXSID901007381

FormulaC26H23FIN5O4

Mol. Weight615.4 g/mol

SMILESCC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5

Data Sources

PubChem · compound 11707110Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

trametinib (CAS 871700-17-3) https://chemicalindependence.com/chemical/871700-17-3/ PubChem: 11707110. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/11707110 FDA National Drug Code directory: CAS 871700-17-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293379 for CAS 871700-17-3. Reporting year: 2024. https://usatrade.census.gov/