Mannitol

Drug ingredient

CAS 87-78-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$46M

Top sourceItaly 78%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories.

Where It Comes From

Customs basis: HS 290543 · exact

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 78%ItalyCN 18%ChinaDE 2%GermanyIN 2%India

Japan
Australia

12 FDA-registered drug labelers

Agno Pharma Jiangsu

B. Braun Medical Inc.

Baxter Healthcare Company

Fresenius Kabi USA, LLC

Henry Schein, Inc.

HF Acquisition Co LLC, DBA HealthFirst

Hospira, Inc.

Hunan Jiudian Pharmaceutical Co.,Ltd.

ICU Medical Inc.

MARYHELENE ENTERPRISES INC

ProPharma Distribution

Roquette Freres SA

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Mannitol
•Osmitrol
•QR PAIN
•Sorbitol-Mannitol

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$0.50/gA2B Chem LLC

CountryUnited States

Pack$50.00 / 100 g

Purity95%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
Combi-Blocks, Inc.	United States	$0.50	100 g	95%
AA BLOCKS	United States	$0.63	100 g	95%
Aaron Chemicals LLC	Hong Kong	$70.64	25 g	50%
Angene Chemical	China → Hong Kong	$71.00	25 g	50%
Angene International Limited	United States	$96.80	5 g	98%
Chengdu Biopurify Phytochemicals Ltd.	China	$142.00	1 g	98%
Labotest KG	Germany	$217.80	5000 mg	90%
ChemFaces	China	$1500.00	20 mg	98%
Vitas M Chemical Limited	Hong Kong	$3170.00	100 mg	90%
TimTec, LLC (back-ordered)	United States	$32000.00	15 mg	94%

Chemical Identity

CAS87-78-5

PubChem CIDNot recorded

DTXSIDDTXSID30858955

FormulaC6H14O6

Mol. Weight182.172 g/mol

SMILESOC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

Data Sources

EPA TSCA InventoryRetrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Mannitol (CAS 87-78-5) https://chemicalindependence.com/chemical/87-78-5/ EPA TSCA Inventory: CAS 87-78-5. Retrieved 2026-10-04. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: CAS 87-78-5. Retrieved 2026-10-04. https://open.fda.gov/data/ndc/ US Census international trade: HS 290543 for CAS 87-78-5. Reporting year: 2024. https://usatrade.census.gov/