isosorbide dinitrate

Drug ingredient

CAS 87-33-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$3.5B

Top sourceIreland 57%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293299 · basket

These shares come from HS customs code 293299, which covers 229 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 57%IrelandNL 24%NetherlandsCH 8%SwitzerlandCN 5%ChinaIT 2%Italy

United Kingdom
Japan
Germany
Spain
Israel
Canada
Brazil
Vietnam
Ukraine
New Zealand
Belgium
Mexico
Singapore
Taiwan
South Korea
Sweden
South Africa
Egypt
Indonesia
Lithuania
Finland
Hungary
Czech Republic
Hong Kong
Malaysia
Slovakia
Australia
Russia
Jordan
Latvia
Argentina
Slovenia
Malta
Poland
Denmark
Austria

25 FDA-registered drug labelers

A2A Integrated Pharmaceuticals

Advagen Pharma Ltd

American Health Packaging

AvPAK

Azurity Pharmaceuticals, Inc.

BluePoint Laboratories

Bryant Ranch Prepack

Cardinal Health 107, LLC

Dipharma Francis Srl

DOTTIKON EXCLUSIVE SYNTHESIS AG

Endo USA, Inc.

Golden State Medical Supply, Inc.

Hikma Pharmaceuticals USA Inc.

i3 Pharmaceuticals, LLC

Ingenus Pharmaceuticals, LLC

Major Pharmaceuticals

NCS HealthCare of KY, LLC dba Vangard Labs

Northstar Rx LLC

Oceanside Pharmaceuticals

Proficient Rx LP

REMEDYREPACK INC.

Sandoz Inc.

Wilshire Pharmaceuticals

Zydus Lifesciences Limited

Zydus Pharmaceuticals (USA) Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Isosorbide dinitrate
•isosorbide dinitrate and hydralazine hydrochloride
•Isosorbide
•BiDil

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS87-33-2

PubChem CID6883

DTXSIDDTXSID0045832

FormulaC6H8N2O8

Mol. Weight236.14 g/mol

SMILESC1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]

Data Sources

PubChem · compound 6883Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

isosorbide dinitrate (CAS 87-33-2) https://chemicalindependence.com/chemical/87-33-2/ PubChem: 6883. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6883 EPA TSCA Inventory: CAS 87-33-2. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293299 for CAS 87-33-2. Reporting year: 2024. https://usatrade.census.gov/