nirogacestat

Drug ingredient

CAS 865773-15-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$114M

Top sourceChina 26%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy

Australia
Brazil
Czech Republic
Ireland
Sweden
Ukraine
Poland
United Arab Emirates
Hungary
Israel
Netherlands
Canada
Saudi Arabia
Greece
Belgium
Austria
Latvia
Singapore
Denmark

2 FDA-registered drug labelers

Patheon France S.A.S

SpringWorks Therapeutics, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Ogsiveo

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS865773-15-5

PubChem CID46224413

DTXSIDDTXSID60235679

FormulaC27H41F2N5O

Mol. Weight489.6 g/mol

SMILESCCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F

Data Sources

PubChem · compound 46224413Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

nirogacestat (CAS 865773-15-5) https://chemicalindependence.com/chemical/865773-15-5/ PubChem: 46224413. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/46224413 FDA National Drug Code directory: CAS 865773-15-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 865773-15-5. Reporting year: 2024. https://usatrade.census.gov/