Linaclotide

Drug ingredient

CAS 851199-59-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.2B

Top sourceSweden 57%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 300249 · basket

These shares come from HS customs code 300249, which is a broad customs category that also covers chemicals outside this dataset. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SE 57%SwedenBE 10%BelgiumKR 6%South KoreaAT 5%AustriaDE 4%Germany

Japan
Singapore
Australia
Uruguay
Mexico
Israel
Spain
Finland
Argentina
Estonia
New Zealand
Slovenia
Brazil
Czech Republic
Hungary
Slovakia
South Africa
Taiwan

9 FDA-registered drug labelers

Allergan, Inc.

Aurobindo Pharma Limited

Chengdu Shengnuo Biopharm Co. Ltd.

Corden Pharma Colorado, Inc.

Hangzhou XinHan Biopharma Co., Ltd.

Hybio Pharmaceutical Co. Ltd

MSN Life Sciences Private Limited

Polypeptide Laboratories Inc

SUN PHARMACEUTICAL INDUSTRIES, INC.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Linzess

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS851199-59-2

PubChem CID16158208

DTXSIDDTXSID90234256

FormulaC59H79N15O21S6

Mol. Weight1526.8 g/mol

SMILESCC1C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)C(=O)NC(CSSCC(C(=O)N3)N)C(=O)NC(C(=O)N5CCCC5C(=O)N1)CC(=O)N)CC6=CC=C(C=C6)O)CCC(=O)O

Data Sources

PubChem · compound 16158208Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Linaclotide (CAS 851199-59-2) https://chemicalindependence.com/chemical/851199-59-2/ PubChem: 16158208. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/16158208 FDA National Drug Code directory: CAS 851199-59-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 300249 for CAS 851199-59-2. Reporting year: 2024. https://usatrade.census.gov/