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Afatinib

Drug ingredient

CAS 850140-72-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 850140-72-6
US productionNot reported
Import value, 2024$6.4B
Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India
1 FDA-registered drug labeler
Boehringer Ingelheim Pharmaceuticals, Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Gilotrif
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$10.48/gAaron Chemicals LLC
CountryHong Kong
Pack$262.00 / 25 g
Purity99%
Vendors32 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

31 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$10.6025 g99%
AA BLOCKSUnited States$17.4025 g99%
BLD Pharmatech GmbHGermany$20.0025 g99%
BLD Pharmatech Ltd.China$20.0025 g99%
Combi-Blocks, Inc.United States$20.05100 g98%
Ambeed, Inc.United States$22.0025 g99%
A2B Chem LLCUnited States$22.405 g98%
BLD Pharmatech Co., LimitedUnited States$28.4825 g98%
Accela ChemBioUnited States$33.001 g98%
Fluorochem EUGermany$47.675 g98%
Angene International LimitedUnited States$52.001 g98%
TargetMol ChemicalsChina → United States$59.001 g99.99%
Fluorochem UKUnited Kingdom$74.36250 mg99%
AK Scientific SpecializedUnited States$90.005 g95%
AstaTech, IncUnited States$128.005 g95%
AK Scientific, Inc.United States$129.405 g98%
MolnovaChina$130.00200 mg99%
TargetMol Chemicals USUnited States$150.00200 mg99.99%
MedChemExpress MCESweden$251.68250 mg99.98%
MedKoo Biosciences, IncUnited States$270.005 g98%
Cayman EuropeEstonia$541.451 g95%
Apollo Scientific UKUnited Kingdom$1225.00200 mg—
AstaTech (2 weeks)United States$1920.00250 mg98%
ChemFacesChina$2000.0020 mg98%
AngeneChina → Hong Kong$2500.0030 mg99%
Apexbio Technology LLCUnited States$2500.0050 mg98.83%
Key Organics Ltd.United Kingdom$2760.0050 mg97%
ChemsceneUnited States$2900.0050 mg—
Sigma-Aldrich (Rush Stock)Germany$5992.8050 mg—
Sigma-AldrichGermany$5992.8050 mg—
Axon MedchemNetherlands$9600.0025 mg99%

Chemical Identity

CAS850140-72-6
PubChem CID10184653
DTXSIDDTXSID20893451
FormulaC24H25ClFN5O3
Mol. Weight485.9 g/mol
SMILESCN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Data Sources

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Brief citations

Afatinib (CAS 850140-72-6) https://chemicalindependence.com/chemical/850140-72-6/ PubChem: 10184653. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/10184653 FDA National Drug Code directory: CAS 850140-72-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 850140-72-6. Reporting year: 2024. https://usatrade.census.gov/