Lorazepam

Drug ingredientActive Shortage

CAS 846-49-1

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$10M

Top sourceItaly 73%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293391 · basket

These shares come from HS customs code 293391, which covers 14 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 73%ItalyIN 21%IndiaIL 4%IsraelFI 1%Finland

China
Switzerland
Germany

45 FDA-registered drug labelers

A-S Medication Solutions

Advanced Rx of Tennessee, LLC

Almatica Pharma LLC

American Health Packaging

Amneal Pharmaceuticals LLC

ANI Pharmaceuticals, Inc.

Aphena Pharma Solutions - Tennessee, LLC

Asclemed USA Inc.

Aurolife Pharma LLC

Bausch Health US LLC

Bryant Ranch Prepack

Cambrex Profarmaco Milano Srl

Centaur Pharmaceuticals Private Limited

Chartwell RX, LLC

Civica, Inc.

Clinical Solutions Wholesale, LLC

DIRECT RX

Evonik Operations GmbH

F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

Fresenius Kabi USA, LLC

Golden State Medical Supply, Inc.

Hikma Pharmaceuticals USA Inc.

Hospira, Inc.

International Medication Systems, Limited

KALINTIS HEALTHCARE PRIVATE LIMITED

Leading Pharma, LLC

LETCO MEDICAL, LLC

Major Pharmaceuticals

Malladi Drugs & Pharmaceuticals Limited

NuCare Pharmaceuticals, Inc.

NURAY CHEMICALS PRIVATE LIMITED

PD-Rx Pharmaceuticals, Inc.

Pharmaceutical Associates, Inc.

PharmPak, Inc.

Preferred Pharmaceuticals Inc.

Professional Compounding Centers of America

Professional Compounding Centers of America dba PCCA

Proficient Rx LP

R.L.Fine Chem Private Limited

RedPharm Drug, Inc.

REMEDYREPACK INC.

Rising Pharma Holdings, Inc.

STHREE CHEMICALS PRIVATE LIMITED

SUN PHARMACEUTICAL INDUSTRIES INC

Teva Pharmaceuticals USA, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Lorazepam
•Loreev XR
•Ativan

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Lorazepam Injection
Shortage listed since May 3, 2018
Manufacturer reports: 2 unavailable, 2 limited, 1 available

See all current drug shortages

Chemical Identity

CAS846-49-1

PubChem CID3958

DTXSIDDTXSID7023225

FormulaC15H10Cl2N2O2

Mol. Weight321.2 g/mol

SMILESC1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl

Data Sources

PubChem · compound 3958Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Lorazepam (CAS 846-49-1) https://chemicalindependence.com/chemical/846-49-1/ PubChem: 3958. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3958 FDA National Drug Code directory: CAS 846-49-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 846-49-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293391 for CAS 846-49-1. Reporting year: 2024. https://usatrade.census.gov/