Riboflavin

Drug ingredient

CAS 83-88-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$44M

Top sourceChina 60%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293623 · narrow

These shares come from HS customs code 293623, which covers 3 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 60%ChinaDE 20%GermanyKR 18%South KoreaIN 1%IndiaZA 1%South Africa

Poland
United Kingdom

37 FDA-registered drug labelers

A-S Medication Solutions

Acella Pharmaceuticals, LLC

Advanced Pharmaceutical Services, Inc. Dba Affordable Quality Pharmaceuticals

ANUBIS COSMETICS SL

Apotheca Company

Avion Pharmaceuticals, LLC

BioActive Nutritional

BioActive Nutritional, Inc.

Bispit Canada Ltd.

Blue Heron Pharmaceuticals, LLC

BonGeo Pharmaceuticals, Inc.

Bryant Ranch Prepack

CarWin Pharmaceutical Associates, LLC

Deseret Biologicals, Inc.

Dr. Donna Restivo DC

Eight and Company L.L.C

Energetix Corporation

Energique, Inc.

Exeltis USA, Inc.

Guna spa

Hillestad Pharmaceuticals USA

Integrative Health Alliance

Liddell Laboratories, Inc.

METHOD PHARMACEUTICALS, LLC

Mission Pharmacal Company

Nutritional Specialties, Inc.

Oncora Pharma, LLC

Patrin Pharma, Inc.

ProBLEN

Professional Complementary Health Formulas

Pure Source, LLC

PureTek Corporation

REMEDYREPACK INC.

Seton Pharmaceuticals

U.S. Pharmaceutical Corporation

WINDER LABORATORIES, LLC

WOMENS CHOICE PHARMACEUTICALS LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 97 drug and cosmetic product listings (FDA).

•Anubis Barcelona Regul Oil
•Dialyvite
•Quflora Pediatric
•Spinalmax
•Glucoreg
•Telomere - DNA
•Nestabs Prenatal Multi-vitamin/Mineral Supplement
•Integra Plus

Show all 97

•Floriva
•Multivitamin with Fluoride
•Flotrex
•Davimet-M
•Prenatryl
•Ventrixyl Fe
•B-Balance Liquescence 3003
•Brain Enhancement Liquescence 3006
•Vitafol One
•Vitafol Fe Plus
•GUNA-Liver
•Bio Cytotox Phase
•Bio Co-Enzyme Phase
•Mitochondria PRO
•Concept OB
•M-Natal Plus
•Vitrexate
•Venexa
•Neuro-Chord
•Se-Tan PLUS
•PureVit DualFe Plus
•Vitranol Fe
•Pretrate
•Folitin-Z
•Cellular Oxygenator Drops 2095
•Multi-Vit-Flor
•Dialyvite 5000
•Dialyvite 3000
•Prenatal Vitamins Plus Low Iron
•Prenatrix
•Multitam
•Livita Children
•Vita-Rx Diabetic Vitamin
•Prenate Elite
•Dialyvite with Zinc
•TriStart DHA
•NADH Plus
•Adaptagen
•Multitol-M
•Davimet with Iron
•Vitrexyl plus Iron
•Ribotin-E
•Livita Adults
•Brain Liquescence
•Lunavira
•GUNA-CELL
•PNV-Select
•BACT Combination
•CitraNatal 90 DHA
•Vital Skin Hair Nails
•Vitrexate FE
•Ventrixyl
•Vitramyn
•Davimet
•Viru-Chord
•Anubis Barcelona
•B Complex Liquescence
•Vitafol Ultra
•Omeosport
•Prenatol-M
•Davimet with Fluoride
•Foliflex
•Hair and Nail Tonic
•Prenatal Plus Vitamins
•Methylation Assist Liquescence
•Cellular Oxygenator
•Strovite One Caplets
•Lumavex
•Matronex
•Se-Natal 19 Chewable
•Finazol
•Vitrexyl
•Vitranol
•Zintrexyl-C
•Dexatran
•Adaptopath
•Essential Weight LOSS
•Dialyvite Supreme D
•Se-Natal 19
•Concept DHA
•Cell Energy Performance Drops 2048
•Compound Oyster Peptide
•JBA Collagen-Electrolyte Mocktail
•Metabolism
•Multivitamin
•Diatrol
•Prometa
•Venexa FE
•NS Support

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Riboflavin 5-phosphate Ophthalmic Solution
Shortage listed since January 20, 2026

See all current drug shortages

Vendor Pricing

$20.00/gTargetMol Chemicals

CountryChina (registered: United States)

Pack$40.00 / 2 g

Purity99.43%

Vendors8 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

7 more vendors

Vendor	Country	$/g	Pack	Purity
CliniSciences GmbH	Switzerland	$32.25	1 g	98%
TargetMol Chemicals US	United States	$33.00	1 g	99.43%
Interbioscreen	Hong Kong	$64.50	10 g	95%
Labotest KG	Germany	$217.80	5000 mg	90%
Vitas M Chemical Limited	Hong Kong	$360.00	1 g	90%
Maybridge, Ltd.	United Kingdom	$2414.30	100 mg	90%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%

Chemical Identity

CAS83-88-5

PubChem CID493570

DTXSIDDTXSID8021777

FormulaC17H20N4O6

Mol. Weight376.4 g/mol

SMILESCC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(CO)O)O)O

Data Sources

PubChem · compound 493570Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Riboflavin (CAS 83-88-5) https://chemicalindependence.com/chemical/83-88-5/ PubChem: 493570. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/493570 EPA TSCA Inventory: CAS 83-88-5. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 83-88-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293623 for CAS 83-88-5. Reporting year: 2024. https://usatrade.census.gov/