Loteprednol etabonate

Drug ingredient

CAS 82034-46-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.1B

Top sourceSingapore 82%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293722 · basket

These shares come from HS customs code 293722, which covers 36 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 82%SingaporeGB 15%United KingdomIT 2%Italy

India
Portugal
China
Mexico
Spain
Malaysia
Canada
Israel
Jordan
Belgium

19 FDA-registered drug labelers

Aarti Pharmalabs Limited

ALCON LABORATORIES, INC.

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Amneal Pharmaceuticals NY LLC

ARMAS PHARMACEUTICALS INC.

Bausch & Lomb Americas Inc.

Bausch & Lomb Incorporated

Curia Spain S.A.U.

Farmabios S.p.A.

Industriale Chimica s.r.l.

Isomedix Operations Inc

Lupin Pharmaceuticals, Inc.

NorthStar RxLLC

Oceanside Pharmaceuticals

Padagis US LLC

Sportpharm LLC

SUN PHARMACEUTICAL INDUSTRIES, INC.

ZACH SYSTEM SA

Why It Matters

Sectors

Health

Downstream Uses

Appears in 8 drug and cosmetic product listings (FDA).

•Inveltys
•Loteprednol Etabonate
•Loteprednol etabonate and Tobramycin
•Alrex
•Zylet
•Lotemax
•Lotemax SM
•Eysuvis

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS82034-46-6

PubChem CID444025

DTXSIDDTXSID2046468

FormulaC24H31ClO7

Mol. Weight466.9 g/mol

SMILESCCOC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)C(=O)OCCl

Data Sources

PubChem · compound 444025Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Loteprednol etabonate (CAS 82034-46-6) https://chemicalindependence.com/chemical/82034-46-6/ PubChem: 444025. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/444025 FDA National Drug Code directory: CAS 82034-46-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293722 for CAS 82034-46-6. Reporting year: 2024. https://usatrade.census.gov/