Cilastatin

Drug ingredient

CAS 82009-34-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$760M

Top sourceChina 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293090 · basket

These shares come from HS customs code 293090, which covers 418 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 33%ChinaES 14%SpainCH 9%SwitzerlandIT 7%ItalyIN 7%India

Israel
Croatia
Ukraine
Slovakia
United Arab Emirates
Ireland
Poland
Lithuania
Brazil
Singapore
Australia
Armenia
Hong Kong
Vietnam
Czech Republic
Hungary
Greece
Russia

2 FDA-registered drug labelers

ACS Dobfar S.p.A

Merck Sharp & Dohme LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Recarbrio

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Imipenem and Cilastatin Injection
Shortage listed since January 8, 2026

See all current drug shortages

Chemical Identity

CAS82009-34-5

PubChem CID6435415

DTXSIDDTXSID8048238

FormulaC16H26N2O5S

Mol. Weight358.5 g/mol

SMILESCC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)O)C

Data Sources

PubChem · compound 6435415Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Cilastatin (CAS 82009-34-5) https://chemicalindependence.com/chemical/82009-34-5/ PubChem: 6435415. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6435415 FDA National Drug Code directory: CAS 82009-34-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 82009-34-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293090 for CAS 82009-34-5. Reporting year: 2024. https://usatrade.census.gov/