Treprostinil

Drug ingredient

CAS 81846-19-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$28M

Top sourceItaly 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293750 · basket

These shares come from HS customs code 293750, which covers 11 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 33%ItalyTW 27%TaiwanKR 14%South KoreaHU 13%HungaryGB 4%United Kingdom

Spain
Germany

8 FDA-registered drug labelers

Alembic Pharmaceuticals Inc.

Chirogate International Inc

Dr.Reddy's Laboratories Inc.,

MSN Laboratories Private Limited

Nuray Chemicals Private Limited

Sandoz Inc

Teva Parenteral Medicines, Inc.

United Therapeutics Corporation

Why It Matters

Sectors

Health

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Treprostinil
•Tyvaso DPI
•Remodulin
•Tyvaso
•Orenitram

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS81846-19-7

PubChem CID6918140

DTXSIDDTXSID901021654

FormulaC23H34O5

Mol. Weight390.5 g/mol

SMILESCCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O

Data Sources

PubChem · compound 6918140Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Treprostinil (CAS 81846-19-7) https://chemicalindependence.com/chemical/81846-19-7/ PubChem: 6918140. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6918140 FDA National Drug Code directory: CAS 81846-19-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293750 for CAS 81846-19-7. Reporting year: 2024. https://usatrade.census.gov/