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Cilastatin sodium

Drug ingredient

CAS 81129-83-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 81129-83-1
1 Na⁺
US productionNot reported
Import value, 2024$760M
Top sourceChina 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293090 · basket

These shares come from HS customs code 293090, which covers 418 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 33%ChinaES 14%SpainCH 9%SwitzerlandIT 7%ItalyIN 7%India
5 FDA-registered drug labelers
ACS DOBFAR SPA
Fresenius Kabi USA, LLC
Merck Sharp & Dohme Corp.
Merck Sharp & Dohme LLC
WG Critical Care, LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Imipenem and Cilastatin
  • •Primaxin IV
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS81129-83-1
PubChem CID23663403
DTXSIDDTXSID2046915
FormulaC16H25N2NaO5S
Mol. Weight380.4 g/mol
SMILESCC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)[O-])C.[Na+]

Data Sources

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Brief citations

Cilastatin sodium (CAS 81129-83-1) https://chemicalindependence.com/chemical/81129-83-1/ PubChem: 23663403. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/23663403 FDA National Drug Code directory: CAS 81129-83-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293090 for CAS 81129-83-1. Reporting year: 2024. https://usatrade.census.gov/