Colistimethate sodium

Drug ingredient

CAS 8068-28-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$546M

Top sourceItaly 41%

EPA lists this chemical as inactive, meaning no company reported making, importing or processing it in the US from 2006 to 2016.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294190 · basket

These shares come from HS customs code 294190, which covers 90 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 41%ItalyCN 24%ChinaDK 9%DenmarkHR 6%CroatiaIN 6%India

United Kingdom
Slovakia
Slovenia
Mexico
Canada
Germany
Belgium
Japan
Switzerland
Netherlands
Czech Republic
Uruguay
South Korea
Hong Kong
Portugal
Australia

9 FDA-registered drug labelers

Endo USA, Inc.

Fresenius Kabi USA, LLC

Hebei Shengxue Dacheng Pharmaceutical Co., Ltd.

Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.

Hikma Pharmaceuticals USA Inc.

Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.

Patheon Manufacturing Services LLC

Xellia Pharmaceuticals ApS

Xellia Pharmaceuticals USA LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Coly-Mycin M
•Colistimethate
•Colistimethate Sodium

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS8068-28-8

PubChem CID44585614

DTXSIDDTXSID6045822

FormulaC45H85N13O10

Mol. Weight968.2 g/mol

SMILESCCC(C)CCCCC(=O)NCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(C)C)CCN)CC(C)C)CCN)CCN)CCN)C(C)O

Data Sources

PubChem · compound 44585614Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Colistimethate sodium (CAS 8068-28-8) https://chemicalindependence.com/chemical/8068-28-8/ PubChem: 44585614. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/44585614 EPA TSCA Inventory: CAS 8068-28-8. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 294190 for CAS 8068-28-8. Reporting year: 2024. https://usatrade.census.gov/