Rifaximin

Drug ingredient

CAS 80621-81-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$546M

Top sourceItaly 41%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294190 · basket

These shares come from HS customs code 294190, which covers 90 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 41%ItalyCN 24%ChinaDK 9%DenmarkHR 6%CroatiaIN 6%India

United Kingdom
Slovakia
Slovenia
Mexico
Canada
Germany
Belgium
Japan
Switzerland
Netherlands
Czech Republic
Uruguay
South Korea
Hong Kong
Portugal
Australia

18 FDA-registered drug labelers

A-S Medication Solutions

Alfasigma SpA

Aurobindo Pharma Limited

AX Pharmaceutical Corp

Bausch Health Companies Inc.

Cambrex Profarmaco Milano S.r.l.

Cardinal Health 107, LLC

Chemeca Drugs Private Limited

Clarochem Ireland Ltd.

Granules India Limited

Hetero Drugs Limited

LUPIN LIMITED

MSN Laboratories Private Limited

Olon SpA

Optimus Drugs Private Limited

Salix Pharmaceuticals, Inc.

SUN PHARMACEUTICAL INDUSTRIES, INC.

Willow Birch Pharma, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Xifaxan

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS80621-81-4

PubChem CID6436173

DTXSIDDTXSID7045998

FormulaC43H51N3O11

Mol. Weight785.9 g/mol

SMILESCC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C

Data Sources

PubChem · compound 6436173Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Rifaximin (CAS 80621-81-4) https://chemicalindependence.com/chemical/80621-81-4/ PubChem: 6436173. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6436173 FDA National Drug Code directory: CAS 80621-81-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 294190 for CAS 80621-81-4. Reporting year: 2024. https://usatrade.census.gov/