levoleucovorin calcium

Drug ingredient

CAS 80433-71-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 80433-71-2 — 1 Ca²⁺

US productionNot reported

Import value, 2024$295M

Top sourceChina 56%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293629 · basket

These shares come from HS customs code 293629, which covers 17 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 56%ChinaCH 12%SwitzerlandIN 12%IndiaIT 11%ItalyJP 2%Japan

Spain
Netherlands
Czech Republic
Israel
Guyana
Norway
Australia
Taiwan
Ivory Coast
Honduras
South Korea
Austria
Colombia
Brazil
Mexico
Belgium
South Africa
Turkey
Hong Kong
Chile
Slovenia
Ecuador
Sweden
Vietnam

11 FDA-registered drug labelers

Amneal Pharmaceuticals LLC

Cerbios-Pharma SA

Dr.Reddy's Laboratories Inc

Gland Pharma Limited

GMT Fine Chemicals SA

Hainan Poly Pharm. Co., Ltd.

Hikma Pharmaceuticals USA Inc.

Medisca Inc.

Meitheal Pharmaceuticals Inc

MERCK & CIE

Slate Run Pharmaceuticals

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Levoleucovorin
•Levoleucovorin Calcium

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS80433-71-2

PubChem CID135500522

DTXSIDDTXSID3045564

FormulaC20H21CaN7O7

Mol. Weight511.5 g/mol

SMILESC1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]

Data Sources

PubChem · compound 135500522Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

levoleucovorin calcium (CAS 80433-71-2) https://chemicalindependence.com/chemical/80433-71-2/ PubChem: 135500522. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135500522 FDA National Drug Code directory: CAS 80433-71-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293629 for CAS 80433-71-2. Reporting year: 2024. https://usatrade.census.gov/