Nepafenac

Drug ingredient

CAS 78281-72-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$872M

Top sourceSwitzerland 44%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292429 · basket

These shares come from HS customs code 292429, which covers 203 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CH 44%SwitzerlandCN 19%ChinaIN 12%IndiaJP 9%JapanIE 6%Ireland

Taiwan
United Kingdom
El Salvador
Colombia
Ukraine
Brazil
Guatemala
Belgium
Netherlands
Turkey
Sweden
Greece
Canada
Israel
New Zealand
Latvia
Lithuania
Finland
Slovakia
Australia
Hong Kong
Czech Republic
Armenia
Poland

9 FDA-registered drug labelers

CARBOGEN AMCIS AG

Catalent Micron Technologies, Inc.

Enaltec Labs Private Limited

FDC Limited

Harrow Eye, LLC

Medichem S.A.

Micro Labs Limited

Novartis Pharmaceuticals Corporation

Siegfried Grafton, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Nevanac
•Ilevro

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$52.00/gAaron Chemicals LLC

CountryHong Kong

Pack$260.00 / 5 g

Purity98%

Vendors19 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

18 more vendors

Vendor	Country	$/g	Pack	Purity
MedKoo Biosciences, Inc	United States	$54.50	100 g	98%
Angene Chemical	China → Hong Kong	$55.80	5 g	98%
Combi-Blocks, Inc.	United States	$122.00	5 g	95%
Ambeed, Inc.	United States	$142.60	5 g	98%
A2B Chem LLC	United States	$169.00	1 g	98%
AA BLOCKS	United States	$188.00	1 g	98%
AK Scientific, Inc.	United States	$387.00	1 g	98%
TargetMol Chemicals	China → United States	$476.00	500 mg	99.88%
Angene International Limited	United States	$629.00	1 g	98%
AstaTech (2 weeks)	United States	$851.00	1 g	98%
Molnova	China	$1090.00	100 mg	99%
Apexbio Technology LLC	United States	$1480.00	100 mg	98%
MedChemExpress MCE	Sweden	$1500.40	100 mg	99.56%
Axon Medchem	Netherlands	$2400.00	50 mg	99%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	90%
Sigma-Aldrich (Rush Stock)	Germany	$4088.90	200 mg	—
Sigma-Aldrich	Germany	$4088.90	200 mg	—
Cayman Europe	Estonia	$4391.10	100 mg	98%

Chemical Identity

CAS78281-72-8

PubChem CID151075

DTXSIDDTXSID0048638

FormulaC15H14N2O2

Mol. Weight254.28 g/mol

SMILESC1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N

Data Sources

PubChem · compound 151075Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Nepafenac (CAS 78281-72-8) https://chemicalindependence.com/chemical/78281-72-8/ PubChem: 151075. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/151075 FDA National Drug Code directory: CAS 78281-72-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292429 for CAS 78281-72-8. Reporting year: 2024. https://usatrade.census.gov/