Gadobutrol

Drug ingredient

CAS 770691-21-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 770691-21-9 — 1 Gd³⁺

US productionNot reported

Import value, 2024$148M

Top sourceChina 75%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 284690 · basket

These shares come from HS customs code 284690, which covers 26 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 75%ChinaIT 6%ItalyJP 5%JapanAT 4%AustriaZA 3%South Africa

Israel
Liechtenstein
Russia
Armenia
Vietnam
Norway
Switzerland
Singapore
United Kingdom
Belgium
Czech Republic

6 FDA-registered drug labelers

Bayer HealthCare Pharmaceuticals Inc.

Fresenius Kabi USA, LLC

Hainan Poly Pharm. Co., Ltd.

Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Sionc Pharmaceutical Private Limited

Slate Run Pharmaceuticals, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•gadobutrol
•Gadavist

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS770691-21-9

PubChem CID6102852

DTXSIDDTXSID101027434

FormulaC18H31GdN4O9

Mol. Weight604.7 g/mol

SMILESC1CN(CCN(CCN(CCN1CC(=O)[O-])CC(=O)[O-])C(CO)C(CO)O)CC(=O)[O-].[Gd+3]

Data Sources

PubChem · compound 6102852Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Gadobutrol (CAS 770691-21-9) https://chemicalindependence.com/chemical/770691-21-9/ PubChem: 6102852. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6102852 FDA National Drug Code directory: CAS 770691-21-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 284690 for CAS 770691-21-9. Reporting year: 2024. https://usatrade.census.gov/