Citric acid
Drug ingredientCAS 77-92-9
This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.
US productionCBI
Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.
Import value, 2024$399M
Top sourceCanada 49%
At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.
Why supply is unknownProduction is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023.
Where It Comes From
Customs basis: HS 291814 · exact
EPA reports by year
- 2023
- US production Confidential · Imports Confidential
- 2019
- US production Confidential · Imports Confidential
Source Countries
Country of origin for US imports, from Census customs data (2024).
CA 49%CanadaMY 35%MalaysiaCO 8%ColombiaCN 2%ChinaTR 2%Turkey
- Germany
- Taiwan
- Italy
- Spain
- Georgia
- Israel
- Pakistan
- Japan
- United Kingdom
- Australia
- Jordan
- Lithuania
- Netherlands
- Lebanon
- Egypt
- Chile
- Vietnam
- Switzerland
- South Korea
- Serbia
- Bahamas
EPA-registered manufacturers (7)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Archer Daniels Midland
Brainerd Chemical
Brulin Holding
Cargill, Incorporated
Life Technologies
Show all 7
Minerals Technologies
Primary Products Ingredients Americas
Domestic parents -- activity not disclosed (11)
EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.
Albemarle
Asia Union Electronic Chemicals - Reno
Basstech International
Buckman Laboratories
Cataler North America
Show all 11
Cellmark Basic Materials
Greenchem Industries
Harcros Chemicals
Lamberti Usa
Polyventive
Wego Chemical Group
EPA-registered importers (40)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Basf Se · DE Germany
Clariant International · CH Switzerland
Fuso Chemical · JP Japan
Jungbunzlauer Suisse Ag · CH Switzerland
Kh Chemicals International B V · NL Netherlands
Show all 40
Master Plant-Prod · CA Canada
Reckitt Benckiser Group · GB United Kingdom
3M
Aurorium
Basf
Cascade Columbia
Chemical Distribution Network
Clariant
Coast Southwest
Delta Carbona
Dupont Specialty Products Usa
Gsd Distribution
Haldor Topsoe
Henkel
Honeywell International (123312)
Hubbard-Hall
Jungbunzlauer
Kemira Water Solutions
Kh Chemicals Na
Kic Chemicals
Kik International
Livingston International
P&G
Pmp Fermentation Products
Producers Chemical
Reckitt Benckiser
Solenis
Target
Tarr
Tilley Distribution Middle River
Uzin Utz North America
Valudor Products
Vitusa Products
Wilbur-Ellis Holdings Ii
Wintersun International
1 FDA-registered drug labeler
Nanjing Hongruixing Biological Technology Co., Ltd
Why It Matters
Sectors
HealthAgricultureFoodEnergyConstructionMetals & MiningPlastics & RubberConsumer ProductsPaper & PrintingCore Chemicals
Downstream Uses
Appears in 74 drug and cosmetic product listings (FDA).
- •Swiss BLEU Relief-Calm Antimicrobial Skin Cream
- •ACD-A
- •CPDA-1
- •Anticoagulant Citrate Dextrose A
- •FCS CP
- •Glucoreg
- •Top Value Effervescent Pain Relief
- •Sodium Citrate and Citric Acid
Show all 74
- •CitriPlus
- •Quality Choice Effervescent Antacid and Pain Relief
- •HZ-Chord
- •Aller-Chord F
- •Category V
- •Walgreens Antacid Pain Relief Extra Strength
- •ACD Blood-Pack Units (PL 146 Plastic)
- •Kroger Effervescent Antacid and Pain Relief
- •FCS HP
- •Bio Co-Enzyme Phase
- •Mitochondria PRO
- •AnubisMed
- •Up and Up Antacid and Pain Relief
- •Rite Aid Antacid and Pain Relief
- •Teruflex Blood with Diversion Blood Sampling Arm 70 mL CPDA-1
- •A12 DTX-Kidney
- •XS H2O Liquescence
- •REFL HS
- •Good Sense Effervescent Antacid and Pain Relief
- •teruflex blood bag system with diversion blood sampling arm 70 ml cpda-1
- •Clenpiq
- •Lyme and Co-Infection Nosode
- •Alka-Seltzer Extra Strength
- •Alka-Seltzer Original
- •Endocrinpath
- •Leader Extra Strength Effervescent Antacid and Pain Reliever
- •Anticoagulant Citrate Phosphate Dextrose (CPD) Blood-Pack Units in PL 146 Plastic
- •Liverex I
- •Herbal Diuretic Liquescence 3011
- •Best Choice Effervescent Antacid Pain Relief
- •Isopathic Phenolic Rings
- •Spleenex V
- •Alka Seltzer Originial 1s Blister Pack
- •Alka-Seltzer
- •Care One Original Antacid and Pain Relief
- •Kidnex IV
- •Teruflex Blood Anticoagulant Citrate Phosphate Dextrose Adenine (CPDA-1) for Collection of 450mL of Blood
- •Hepatic-Tone
- •WinCo Foods Effervescent Antacid and Pain Relief
- •Equate Effervescent Antacid and Pain Relief
- •Bromo Seltzer
- •Market Basket Effervescent Antacid and Pain Relief
- •Publix Fast Relief Effervescent
- •Alka-Seltzer Heartburn and Pain
- •Adaptopath
- •Renacidin
- •Walgreens Effervescent Pain Relief
- •CVS Health Antacid and Pain Reliever
- •E-Z-GAS II
- •Signature Care Effervescent Antacid and Pain Relief
- •HEB Extra Strength Effervescent Antacid and Pain Relief
- •Meijer Effervescent Antacid and Pain Relief
- •Spleenex VH
- •Drug Mart Effervescent Pain Relief
- •Cell Energy Performance Drops 2048
- •Quality Choice Extra Strength Effervescent Antacid and Pain Relief
- •Metab
- •TopCare Effervescent Antacid and Pain Relief
- •Effervescent Antacid and Pain Relief
- •Equaline Effervescent Antacid and Pain Relief
- •DG Health Effervescent Antacid and Pain Relief
- •LY-CO
- •Metab 6012
- •A01 Cellular Recharge
- •N03 Exchem
- •CVS Health Extra Strength Antacid and Pain Reliever
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Industrial Uses
Used in 11 sectors as 12 functional roles.
- •Antioxidant in Plastics Product Manufacturing (100%)Processing—incorporation into article
- •pH regulating agent in All Other Chemical Product and Preparation Manufacturing (15%)Processing—incorporation into formulation, mixture, or reaction product
- •Soil amendments (fertilizers) in Pesticide, Fertilizer, and Other Agricultural Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •pH regulating agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •pH regulating agent in Food, beverage, and tobacco product manufacturing (10%)Use—non-incorporative activities
- •Monomers in All Other Basic Organic Chemical ManufacturingProcessing as a reactant
- •Cleaning agent in Paper Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Catalyst in Petroleum Refineries (100%)Use—non-incorporative activities
- •Binder in Primary Metal Manufacturing (100%)Processing—incorporation into article
- •Filler in Primary Metal Manufacturing (100%)Processing—incorporation into article
- •Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing as a reactant
- •Preservative in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Cleaning agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (20%)Processing—incorporation into formulation, mixture, or reaction product
- •Flavoring and nutrient in Food, beverage, and tobacco product manufacturing (80%)Processing—incorporation into formulation, mixture, or reaction product
- •Surface modifier in Fabricated Metal Product ManufacturingUse—non-incorporative activities
- •pH regulating agent in ConstructionProcessing—incorporation into article
Chemical Identity
CAS77-92-9
PubChem CID311
DTXSIDDTXSID3020332
FormulaC6H8O7
Mol. Weight192.12 g/mol
SMILESC(C(=O)O)C(CC(=O)O)(C(=O)O)O
Data Sources
- EPA CompTox (DSSTox) · DTXSID3020332Retrieved 2026-04-06
- PubChem · compound 311Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- FDA National Drug Code directoryRetrieved 2026-04-07
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Citric acid (CAS 77-92-9) https://chemicalindependence.com/chemical/77-92-9/ EPA CompTox (DSSTox): DTXSID3020332. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 PubChem: 311. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/311 EPA Chemical Data Reporting: 77-92-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 77-92-9. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291814 for CAS 77-92-9. Reporting year: 2024. https://usatrade.census.gov/