Tromethamine

Drug ingredientActive Shortage

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 77-86-1
US ProductionCBI
Import Value$197M
Top SourceChina 36%

The EPA did not publish how much of this chemical companies made or imported, or marked that amount confidential. Without that volume, ACID cannot calculate import dependency.

Where It Comes From

Customs basis: HS 292219 · basket

These shares come from HS customs code 292219, which covers 70 chemicals in total. They estimate the bucket's origin mix, not this chemical specifically.

Source Countries
CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary
EPA-registered manufacturers (1)
Angus Chemical
EPA-registered importers (2)
Avantor
Emd Holding
8 FDA-registered drug labelers
ANUBIS COSMETICS SL
B. Braun Medical Inc.
BioSpectra
Corden Pharma Boulder, Inc.
Corden Pharma Colorado, Inc.
Hospira, Inc.
MILLA PHARMACEUTICALS INC.
Pfanstiehl, Inc.

Why It Matters

Sectors
Core ChemicalsHealth
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •THAM
  • •AnubisMed
  • •Tromethamine
  • •Anubis Barcelona Protective Line
FDA Shortage Status
Active Shortage
Shortage History
current

Ketorolac Tromethamine Injection

03/26/2018

Available

current

Ketorolac Tromethamine Injection

06/06/2018

Available

to be discontinued

Ketorolac Tromethamine Tablet

04/20/2026

current

Ketorolac Tromethamine Injection

03/23/2018

Unavailable

current

Ketorolac Tromethamine Injection

06/06/2018

Unavailable

current

Ketorolac Tromethamine Injection

03/23/2018

Available

current

Ketorolac Tromethamine Injection

03/26/2018

Unavailable

current

Ketorolac Tromethamine Injection

03/26/2018

Limited Availability

Industrial Uses

Used in 3 sectors as 2 functional roles.

  • •Intermediate in All Other Basic Organic Chemical Manufacturing (1%)Processing as a reactant
  • •Laboratory chemicals in Pharmaceutical and Medicine Manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product
  • •Laboratory chemicals in All Other Chemical Product and Preparation ManufacturingProcessing—repackaging

Vendor Pricing

$0.02/gAaron Chemicals LLC
CountryHong Kong
Pack$532.00 / 25 kg
Purity99%
Vendors30 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

29 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.031 kg99%
A2B Chem LLCUnited States$0.041 kg99.5%
Apollo Scientific USUnited Kingdom$0.045 kg99.9%
AA BLOCKSUnited States$0.051 kg98%
Fluorochem UKUnited Kingdom$0.055 kg99%
ChemsceneUnited States$0.051 kg—
BLD Pharmatech GmbHGermany$0.061 kg98%
BLD Pharmatech Ltd.China$0.061 kg98%
Fluorochem EUGermany$0.061 kg99%
MedChemExpress MCESweden$0.071 kg—
Sigma-Aldrich (Rush Stock)Germany$0.08100 kg99%
Sigma-AldrichGermany$0.08100 kg99%
BLD Pharmatech Co., LimitedUnited States$0.111 kg98%
Ambeed, Inc.United States$0.111 kg98%
AK Scientific SpecializedUnited States$0.111 kg98%
AstaTech, IncUnited States$0.11500 g95%
ALFA AESARGermany$0.132.5 kg99%
MedKoo Biosciences, IncUnited States$0.205 kg98%
AK Scientific, Inc.United States$0.211 kg99%
Combi-Blocks, Inc.United States$0.251 kg95%
Angene International LimitedUnited States$0.35100 g98%
AldlabUnited States$0.5525 g95%
InterbioscreenHong Kong$10.0010 g95%
MolnovaChina$52.00500 mg99%
Labotest KGGermany$217.805000 mg90%
Otava, Ltd.Ukraine$460.00250 mg95%
Apexbio Technology LLCUnited States$1000.0050 mg98%
AngeneChina → Hong Kong$4266.6730 mg99%
Key Organics Ltd.United Kingdom$6900.0010 mg95%

Chemical Identity

CAS77-86-1
PubChem CID6503
DTXSIDDTXSID2023723
FormulaC4H11NO3
Mol. Weight121.14 g/mol
SMILESC(C(CO)(CO)N)O

Data Sources

DTXSID20237232026-04-06

https://doi.org/10.23645/epacomptox.5588566

Archive: data/sources/comptox/dsstox_identifiers.csv

65032026-04-06

https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/6503/property/MolecularFormula,MolecularWeight,CanonicalSMILES,InChIKey/JSON

Archive: data/sources/pubchem_properties/6503.json

77-86-12026-04-24

https://www.epa.gov/chemical-data-reporting

Archive: data/sources/epa_cdr/2020_cdr.csv

CAS 77-86-12026-06-13

https://api.fda.gov/drug/shortages.json

Archive: data/sources/fda/shortages/shortages.json

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