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Tromethamine

Drug ingredientActive Shortage

CAS 77-86-1

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 77-86-1
US productionCBI
Import value, 2024$197M
Top sourceChina 36%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292219 · basket

EPA reports by year
2023
US production Confidential · Imports Confidential
2019
US production Confidential · Imports Confidential

These shares come from HS customs code 292219, which covers 167 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary
EPA-registered manufacturers (1)
Angus Chemical
EPA-registered importers (2)
Avantor
Thermo Fisher Scientific
8 FDA-registered drug labelers
ANUBIS COSMETICS SL
B. Braun Medical Inc.
BioSpectra
Corden Pharma Boulder, Inc.
Corden Pharma Colorado, Inc.
Hospira, Inc.
MILLA PHARMACEUTICALS INC.
Pfanstiehl, Inc.

Why It Matters

Sectors
HealthAgricultureConsumer ProductsCore Chemicals
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •THAM
  • •AnubisMed
  • •Tromethamine
  • •Anubis Barcelona Protective Line
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Ketorolac Tromethamine Injection

    Shortage listed since March 23, 2018

    Manufacturer reports: 3 unavailable, 1 limited, 3 available

  • to be discontinued

    Ketorolac Tromethamine Tablet

    Shortage listed since April 20, 2026

See all current drug shortages

Industrial Uses

Used in 3 sectors as 2 functional roles.

  • •Intermediate in All Other Basic Organic Chemical Manufacturing (1%)Processing as a reactant
  • •Laboratory chemicals in Pharmaceutical and Medicine Manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product
  • •Laboratory chemicals in All Other Chemical Product and Preparation ManufacturingProcessing—repackaging

Vendor Pricing

$0.02/gAaron Chemicals LLC
CountryHong Kong
Pack$532.00 / 25 kg
Purity99%
Vendors30 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

29 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.031 kg99%
A2B Chem LLCUnited States$0.041 kg99.5%
Apollo Scientific USUnited Kingdom$0.045 kg99.9%
AA BLOCKSUnited States$0.051 kg98%
Fluorochem UKUnited Kingdom$0.055 kg99%
ChemsceneUnited States$0.051 kg—
BLD Pharmatech GmbHGermany$0.061 kg98%
BLD Pharmatech Ltd.China$0.061 kg98%
Fluorochem EUGermany$0.061 kg99%
MedChemExpress MCESweden$0.071 kg—
Sigma-Aldrich (Rush Stock)Germany$0.08100 kg99%
Sigma-AldrichGermany$0.08100 kg99%
BLD Pharmatech Co., LimitedUnited States$0.111 kg98%
Ambeed, Inc.United States$0.111 kg98%
AK Scientific SpecializedUnited States$0.111 kg98%
AstaTech, IncUnited States$0.11500 g95%
ALFA AESARGermany$0.132.5 kg99%
MedKoo Biosciences, IncUnited States$0.205 kg98%
AK Scientific, Inc.United States$0.211 kg99%
Combi-Blocks, Inc.United States$0.251 kg95%
Angene International LimitedUnited States$0.35100 g98%
AldlabUnited States$0.5525 g95%
InterbioscreenHong Kong$10.0010 g95%
MolnovaChina$52.00500 mg99%
Labotest KGGermany$217.805000 mg90%
Otava, Ltd.Ukraine$460.00250 mg95%
Apexbio Technology LLCUnited States$1000.0050 mg98%
AngeneChina → Hong Kong$4266.6730 mg99%
Key Organics Ltd.United Kingdom$6900.0010 mg95%

Chemical Identity

CAS77-86-1
PubChem CID6503
DTXSIDDTXSID2023723
FormulaC4H11NO3
Mol. Weight121.14 g/mol
SMILESC(C(CO)(CO)N)O

Data Sources

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Brief citations

Tromethamine (CAS 77-86-1) https://chemicalindependence.com/chemical/77-86-1/ EPA CompTox (DSSTox): DTXSID2023723. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID2023723 PubChem: 6503. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6503 EPA Chemical Data Reporting: 77-86-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA Drug Shortages: CAS 77-86-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292219 for CAS 77-86-1. Reporting year: 2024. https://usatrade.census.gov/