Dimethyl sulfate

CAS 77-78-1

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$208M

Top sourceChina 28%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292090 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292090, which covers 98 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 28%ChinaKR 17%South KoreaIT 13%ItalyIN 10%IndiaDE 9%Germany

Poland
Switzerland
Ireland
Canada
Lithuania
Netherlands
Brazil
Malaysia
Hungary
Czech Republic
Saudi Arabia
Slovakia
Ukraine
Turkey

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Chemours

EPA-registered importers (6)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Bayer Ag · DE Germany

Basf

Bayer Us Holding

Show all 6

Iofina Chemical

Why It Matters

Sectors

HealthAgricultureConsumer ProductsCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 5 sectors as 1 functional role.

•Intermediate in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (100%)Processing as a reactant
•Intermediate in All Other Basic Organic Chemical Manufacturing (10%)Processing as a reactant
•Intermediate in Pharmaceutical and Medicine Manufacturing (1%)Processing as a reactant
•Intermediate in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (50%)Processing as a reactant
•Intermediate in All Other Chemical Product and Preparation Manufacturing (1%)Processing as a reactant

Vendor Pricing

$24.00/gInterbioscreen

CountryHong Kong

Pack$240.00 / 10 g

Purity95%

Vendors3 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

2 more vendors

Vendor	Country	$/g	Pack	Purity
Labotest KG	Germany	$217.80	5000 mg	90%
Otava, Ltd.	Ukraine	$460.00	250 mg	95%

Chemical Identity

CAS77-78-1

PubChem CID6497

DTXSIDDTXSID5024055

FormulaC2H6O4S

Mol. Weight126.13 g/mol

SMILESCOS(=O)(=O)OC

Data Sources

EPA CompTox (DSSTox) · DTXSID5024055Retrieved 2026-04-06
PubChem · compound 6497Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Dimethyl sulfate (CAS 77-78-1) https://chemicalindependence.com/chemical/77-78-1/ EPA CompTox (DSSTox): DTXSID5024055. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024055 PubChem: 6497. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6497 EPA Chemical Data Reporting: 77-78-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 77-78-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292090 for CAS 77-78-1. Reporting year: 2024. https://usatrade.census.gov/