Phenolphthalein

Drug ingredient

CAS 77-09-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$286M

Top sourceChina 48%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293220 · basket

These shares come from HS customs code 293220, which covers 151 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 48%ChinaIN 15%IndiaJP 7%JapanGB 7%United KingdomCH 7%Switzerland

Mexico
Austria
Indonesia
Czech Republic
Slovakia
Malaysia
Israel
Poland
Vietnam
Ukraine
South Africa
Singapore
Russia
Lithuania
Hungary
Belarus
Brazil
Australia

1 FDA-registered drug labeler

Apex Energetics Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•N02 Petrochem

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$0.04/gAaron Chemicals LLC

CountryHong Kong

Pack$21.00 / 500 g

PurityNot recorded

Vendors22 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

21 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.05	500 g	99%
AA BLOCKS	United States	$0.09	1 kg	99%
A2B Chem LLC	United States	$0.09	500 g	99%
AK Scientific Specialized	United States	$0.10	500 g	95%
Ambeed, Inc.	United States	$0.11	1 kg	99%
Sigma-Aldrich (Rush Stock)	Germany	$0.17	2.5 kg	—
Sigma-Aldrich	Germany	$0.17	2.5 kg	—
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
AK Scientific, Inc.	United States	$0.26	500 g	98%
MedChemExpress MCE	Sweden	$0.30	250 g	99.92%
MedKoo Biosciences, Inc	United States	$0.66	500 g	98%
AstaTech (2 weeks)	United States	$0.99	100 g	95%
Angene International Limited	United States	$3.08	25 g	—
Molnova	China	$45.00	1 g	99%
Apexbio Technology LLC	United States	$64.00	1 g	99.55%
Labotest KG	Germany	$217.80	5000 mg	90%
Vitas M Chemical Limited	Hong Kong	$360.00	1 g	90%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%
Life Chemicals Inc.	Ukraine → Canada	$3100.00	100 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	99%
TimTec, LLC	United States	$9333.33	30 mg	98.55%

Chemical Identity

CAS77-09-8

PubChem CID4764

DTXSIDDTXSID0021125

FormulaC20H14O4

Mol. Weight318.3 g/mol

SMILESC1=CC=C2C(=C1)C(=O)OC2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O

Data Sources

PubChem · compound 4764Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Phenolphthalein (CAS 77-09-8) https://chemicalindependence.com/chemical/77-09-8/ PubChem: 4764. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4764 EPA TSCA Inventory: CAS 77-09-8. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293220 for CAS 77-09-8. Reporting year: 2024. https://usatrade.census.gov/