Trifluoroacetic acid

CAS 76-05-1

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$384M

Top sourceMalaysia 21%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291590 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291590, which covers 588 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

MY 21%MalaysiaDE 13%GermanyNL 13%NetherlandsMX 10%MexicoIT 8%Italy

Singapore
Austria
United Kingdom
Philippines
Canada
Hungary
Turkey
Ukraine
Israel
Denmark
Czech Republic
Slovakia
Norway
Poland
Hong Kong
South Africa
Russia

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Bayer Ag · DE Germany

Bayer Us Holding

Why It Matters

Sectors

HealthAgricultureMetals & Mining

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 1 functional role.

•Intermediate in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (100%)Processing as a reactant
•Intermediate in Miscellaneous ManufacturingProcessing—repackaging
•Intermediate in Pharmaceutical and Medicine ManufacturingProcessing as a reactant

Vendor Pricing

$0.04/gApollo Scientific US

CountryUnited Kingdom

Pack$213.00 / 5 kg

Purity99.9%

Vendors9 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

8 more vendors

Vendor	Country	$/g	Pack	Purity
Fluorochem UK	United Kingdom	$0.05	2.5 kg	99.9%
AK Scientific Specialized	United States	$0.25	500 g	98%
AK Scientific, Inc.	United States	$0.33	500 g	99%
Sigma-Aldrich (Rush Stock)	Germany	$1.56	500 g	99%
Sigma-Aldrich	Germany	$1.56	500 g	99%
Life Chemicals Inc.	Ukraine → Canada	$38.00	500 mg	95%
Otava, Ltd.	Ukraine	$460.00	250 mg	90%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	90%

Chemical Identity

CAS76-05-1

PubChem CID6422

DTXSIDDTXSID9041578

FormulaC2HF3O2

Mol. Weight114.02 g/mol

SMILESC(=O)(C(F)(F)F)O

Data Sources

EPA CompTox (DSSTox) · DTXSID9041578Retrieved 2026-04-06
PubChem · compound 6422Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Trifluoroacetic acid (CAS 76-05-1) https://chemicalindependence.com/chemical/76-05-1/ EPA CompTox (DSSTox): DTXSID9041578. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041578 PubChem: 6422. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6422 EPA Chemical Data Reporting: 76-05-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 76-05-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291590 for CAS 76-05-1. Reporting year: 2024. https://usatrade.census.gov/