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Leflunomide

Drug ingredient

CAS 75706-12-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 75706-12-6
US productionNot reported
Import value, 2024$6.4B
Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India
25 FDA-registered drug labelers
A-S Medication Solutions
Alembic Pharmaceuticals Inc.
Alembic Pharmaceuticals Limited
Apotex Corp.
Aurobindo Pharma Limited
AvKARE
AvPAK
Bryant Ranch Prepack
Burel Pharmaceuticals, LLC
Chartwell RX, LLC
Cipla Ltd.
DARMERICA, LLC
Emcure Pharmaceuticals Limited
Formosa Laboratories, Inc.
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
KVK-Tech, Inc.
Lupin Pharmaceuticals, Inc.
Maprimed S.A.
NuCare Pharmaceuticals, Inc.
OPELLA HEALTHCARE INTERNATIONAL SAS
Professional Compounding Centers of America dba PCCA
RAKSHIT DRUGS PRIVATE LIMITED
sanofi-aventis U.S. LLC
Zydus Lifesciences Limited
Zydus Pharmaceuticals (USA) Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Arava
  • •Leflunomide
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$8.60/gCombi-Blocks, Inc.
CountryUnited States
Pack$860.00 / 100 g
Purity98%
Vendors32 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

31 more vendors
VendorCountry$/gPackPurity
Aaron Chemicals LLCHong Kong$9.69100 g98%
BLD Pharmatech Ltd.China$9.92100 g98%
Angene ChemicalChina → Hong Kong$10.36100 g98%
BLD Pharmatech Co., LimitedUnited States$12.4025 g98%
BLD Pharmatech GmbHGermany$12.4025 g98%
Ambeed, Inc.United States$12.4025 g98%
A2B Chem LLCUnited States$13.3225 g98%
AA BLOCKSUnited States$14.0825 g98%
ChemDiv, Inc.United States$25.0025 g90%
AK Scientific, Inc.United States$39.5225 g98%
Angene International LimitedUnited States$62.0425 g98%
AstaTech (2 weeks)United States$62.8010 g95%
Sigma-Aldrich (Rush Stock)Germany$170.091 g—
Sigma-AldrichGermany$170.091 g—
Fulfilled by MolportLatvia$200.0050 mg98%
MolnovaChina$292.00500 mg99%
TargetMol ChemicalsChina → United States$324.00500 mg99.99%
TargetMol Chemicals EUAustria$360.00200 mg99.99%
MedChemExpress MCESweden$496.10500 mg99.82%
AK Scientific SpecializedUnited States$700.00100 mg99%
MedKoo Biosciences, IncUnited States$750.001 g98%
Axon MedchemNetherlands$768.00250 mg99%
CliniSciences GmbHSwitzerland$1186.8050 mg99%
Cayman EuropeEstonia$1249.50500 mg98%
SpecsNetherlands$1694.0020 mg90%
Princeton BioMolecular Research (SC)United States$2900.00100 mg90%
Vitas M Chemical LimitedHong Kong$3170.00100 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%
Life Chemicals Inc.Ukraine → Canada$4650.00100 mg90%
Key Organics Ltd.United Kingdom$6900.0010 mg97%
TimTec, LLCUnited States$58000.005 mg90%

Chemical Identity

CAS75706-12-6
PubChem CID3899
DTXSIDDTXSID9023201
FormulaC12H9F3N2O2
Mol. Weight270.21 g/mol
SMILESCC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F

Data Sources

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Brief citations

Leflunomide (CAS 75706-12-6) https://chemicalindependence.com/chemical/75706-12-6/ PubChem: 3899. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3899 FDA National Drug Code directory: CAS 75706-12-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 75706-12-6. Reporting year: 2024. https://usatrade.census.gov/