crinecerfont

Drug ingredient

CAS 752253-39-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$447M

Top sourceChina 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293410 · basket

These shares come from HS customs code 293410, which covers 83 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 31%ChinaDE 25%GermanyMX 19%MexicoJP 13%JapanIN 5%India

United Kingdom
Italy
Ukraine
Spain
Netherlands
Poland
Belgium
Canada
Croatia
Bulgaria
Taiwan
Sweden
Slovakia
Slovenia

3 FDA-registered drug labelers

Catalent Pharma Solutions, LLC

Has Healthcare Advanced Synthesis SA

Neurocrine Biosciences, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Crenessity

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Crinecerfont Capsule
Shortage listed since April 28, 2026

See all current drug shortages

Chemical Identity

CAS752253-39-7

PubChem CID5282340

DTXSIDDTXSID10996687

FormulaC27H28ClFN2OS

Mol. Weight483 g/mol

SMILESCC1=C(C=C(C=C1)C(CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F

Data Sources

PubChem · compound 5282340Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

crinecerfont (CAS 752253-39-7) https://chemicalindependence.com/chemical/752253-39-7/ PubChem: 5282340. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5282340 FDA National Drug Code directory: CAS 752253-39-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 752253-39-7. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293410 for CAS 752253-39-7. Reporting year: 2024. https://usatrade.census.gov/