Chlorodifluoromethane

CAS 75-45-6

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$1M

Top sourceMexico 79%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023.

Where It Comes From

Customs basis: HS 290371 · exact

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

Source Countries

Country of origin for US imports, from Census customs data (2024).

MX 79%MexicoCA 21%Canada

Domestic parents -- activity not disclosed (3)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Brainerd Chemical

Chemours

Daikin America

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Unique Chemical Technologies

Why It Matters

Sectors

HealthEnergyCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 2 functional roles.

•Intermediate in All Other Basic Organic Chemical Manufacturing (90%)Processing as a reactant
•Refrigerants in All Other Chemical Product and Preparation Manufacturing (1%)Processing—repackaging
•Refrigerants in Industrial Gas Manufacturing (100%)Processing as a reactant

Chemical Identity

CAS75-45-6

PubChem CID6372

DTXSIDDTXSID6020301

FormulaCHClF2

Mol. Weight86.47 g/mol

SMILESC(F)(F)Cl

Data Sources

EPA CompTox (DSSTox) · DTXSID6020301Retrieved 2026-04-06
PubChem · compound 6372Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Chlorodifluoromethane (CAS 75-45-6) https://chemicalindependence.com/chemical/75-45-6/ EPA CompTox (DSSTox): DTXSID6020301. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020301 PubChem: 6372. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6372 EPA Chemical Data Reporting: 75-45-6. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 75-45-6. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290371 for CAS 75-45-6. Reporting year: 2024. https://usatrade.census.gov/