Acetonitrile

CAS 75-05-8

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$281M

Top sourceChina 31%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292690 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292690, which covers 191 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 31%ChinaIT 15%ItalyGB 14%United KingdomIN 11%IndiaJP 8%Japan

South Korea
Spain
Ireland
Ukraine
Malaysia
Brazil
Hong Kong
Latvia
Australia

EPA-registered manufacturers (4)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Shell Plc · GB United Kingdom

Huntsman

Ineos Us I

Shell Petroleum

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Cellmark Basic Materials

EPA-registered importers (11)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Novasol North America · CA Canada

American River Brokerage

Avantor

Doremus Terminal

Frp Services & Co. (America)

Show all 11

Geocycle

Honeywell International (123312)

Icc Industries

Pht International

Tedia

Thermo Fisher Scientific

Why It Matters

Sectors

HealthAgricultureEnergyConstructionPlastics & RubberTextilesConsumer ProductsCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 12 sectors as 6 functional roles.

•Intermediate in Pharmaceutical and Medicine Manufacturing (6%)Processing as a reactant
•Solvent in Pharmaceutical and Medicine Manufacturing (46%)Processing—incorporation into formulation, mixture, or reaction product
•Laboratory chemicals in Wholesale and Retail Trade (48%)Processing—repackaging
•Solvent in Pesticide, Fertilizer, and Other Agricultural Chemical ManufacturingProcessing as a reactant
•Cleaning agent in All other Petroleum and Coal Products Manufacturing (3%)Processing as a reactant
•Laboratory chemicals in All Other Chemical Product and Preparation Manufacturing (15%)Processing—repackaging
•Cleaning agent in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (2%)Processing as a reactant
•Cleaning agent in Pharmaceutical and Medicine Manufacturing (80%)Processing as a reactant
•Intermediate in Petroleum Refineries (100%)Processing as a reactant
•Solvent in All Other Basic Organic Chemical Manufacturing (100%)Processing—repackaging
•Solvent in Plastics Material and Resin Manufacturing (100%)Use—non-incorporative activities
•Fuel in Non-metallic Mineral Product Manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other non-metallic mineral product manufacturing)Processing—repackaging
•Laboratory chemicals in All Other Basic Organic Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
•Laboratory chemicals in ServicesNot Known or Reasonably Ascertainable
•Intermediate in All Other Basic Inorganic Chemical Manufacturing (100%)Processing as a reactant
•Laboratory chemicals in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (5%)Processing—incorporation into formulation, mixture, or reaction product
•Dye in Textiles, apparel, and leather manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.12/gSigma-Aldrich (Rush Stock)

CountryGermany

Pack$18425.59 / 150 kg

Purity99.5%

Vendors3 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

2 more vendors

Vendor	Country	$/g	Pack	Purity
Sigma-Aldrich	Germany	$0.12	150 kg	99.5%
Labotest KG	Germany	$217.80	5000 mg	90%

Chemical Identity

CAS75-05-8

PubChem CID6342

DTXSIDDTXSID7020009

FormulaC2H3N

Mol. Weight41.05 g/mol

SMILESCC#N

Data Sources

EPA CompTox (DSSTox) · DTXSID7020009Retrieved 2026-04-06
PubChem · compound 6342Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Acetonitrile (CAS 75-05-8) https://chemicalindependence.com/chemical/75-05-8/ EPA CompTox (DSSTox): DTXSID7020009. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020009 PubChem: 6342. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6342 EPA Chemical Data Reporting: 75-05-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 75-05-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292690 for CAS 75-05-8. Reporting year: 2024. https://usatrade.census.gov/