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Alprostadil

Drug ingredient

CAS 745-65-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 745-65-3
US productionNot reported
Import value, 2024$28M
Top sourceItaly 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293750 · basket

These shares come from HS customs code 293750, which covers 11 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 33%ItalyTW 27%TaiwanKR 14%South KoreaHU 13%HungaryGB 4%United Kingdom
17 FDA-registered drug labelers
Bills Biotech pvt ltd.
Chirogate International Inc
DARMERICA, LLC
Endo USA, Inc.
EUROAPI Hungary Ltd.
Everlight Chemical Industrial Corporation Kuanyin II Plant
LETCO MEDICAL, LLC
Medisca Inc.
Meitheal Pharmaceuticals Inc.
Ono Pharmaceutical Co., Ltd.
Pharmacia & Upjohn Company LLC
Pharmacia and Upjohn Company LLC
Professional Compounding Centers of America dba PCCA
Qingdao Biopeptek Co., Ltd.
SCH Global Services Private Limited
Spectrum Laboratory Products, Inc.
YS Life Science Co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

  • •Caverject
  • •Prostin VR Pediatric
  • •Alprostadil
  • •Caverject Impulse
  • •Edex
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS745-65-3
PubChem CID5280723
DTXSIDDTXSID9022578
FormulaC20H34O5
Mol. Weight354.5 g/mol
SMILESCCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O

Data Sources

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Brief citations

Alprostadil (CAS 745-65-3) https://chemicalindependence.com/chemical/745-65-3/ PubChem: 5280723. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5280723 FDA National Drug Code directory: CAS 745-65-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293750 for CAS 745-65-3. Reporting year: 2024. https://usatrade.census.gov/