Leuprolide acetate

Drug ingredient

CAS 74381-53-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$16.4B

Top sourceIreland 94%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293719 · basket

These shares come from HS customs code 293719, which covers 53 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 94%IrelandAR 4%ArgentinaCN 1%ChinaDK 1%Denmark

Switzerland
Sweden
India
Spain
Israel
Austria
Belgium
Netherlands
Italy
Hong Kong
Brazil
United Kingdom
Germany
Canada
Australia
Japan
New Zealand
Latvia
South Korea
Taiwan
Estonia
Uruguay

19 FDA-registered drug labelers

Aspen Oss B.V.

Aurobindo Pharma Limited

Bachem AG

BCN PEPTIDES SA

Darmerica, LLC

Hemmo Pharmaceuticals Pvt. Ltd

Hubei JXBio Pharmaceutical Co.,Ltd

MEDISCA Inc.

Piramal Pharma Limited

PolyPeptide Laboratories, Pvt. Ltd.

Professional Compounding Centers of America

SUN PHARMACEUTICAL INDUSTRIES, INC.

Synergy Health AST

Takeda Pharmaceutical Company Limited

Takeda Pharmaceutical Company LTD

TOLMAR Inc.

URONOVA PHARMACEUTICALS, INC.

Zhejiang Peptites Biotech Co., Ltd.

Zhejiang Supor Pharmaceuticals Co., Ltd

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Eligard
•Vabrinty
•Fensolvi

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS74381-53-6

PubChem CID657180

DTXSIDDTXSID7049009

FormulaC61H88N16O14

Mol. Weight1269.4 g/mol

SMILESCCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6.CC(=O)O

Data Sources

PubChem · compound 657180Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Leuprolide acetate (CAS 74381-53-6) https://chemicalindependence.com/chemical/74381-53-6/ PubChem: 657180. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/657180 FDA National Drug Code directory: CAS 74381-53-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293719 for CAS 74381-53-6. Reporting year: 2024. https://usatrade.census.gov/