methotrexate sodium

Drug ingredientActive Shortage

CAS 7413-34-5

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 7413-34-5 — 2 Na⁺

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

27 FDA-registered drug labelers

A-S Medication Solutions

Accord Healthcare Inc.

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Aurobindo Pharma Limited

Bryant Ranch Prepack

Chartwell RX, LLC

Coupler LLC

Elite Laboratories, Inc.

Eugia US LLC

Excella GmbH & Co. KG

Fermion Oy

Fresenius Kabi USA, LLC

Golden State Medical Supply, Inc.

Hikma Pharmaceuticals USA Inc.

Hospira, Inc.

Medexus Pharma Inc.

MSN Laboratories Private Limited

Mylan Institutional Inc.

Mylan Pharmaceuticals Inc.

NuCare Pharmaceuticals, Inc.

Proficient Rx LP

Safecor Health LLC

Sun Pharmaceutical Industries, Inc.

Teva Parenteral Medicines, Inc.

Teva Pharmaceuticals USA, Inc.

Teva Women's Health, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Methotrexate Sodium
•Methotrexate
•Rasuvo
•Trexall

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Methotrexate Sodium Injection
Shortage listed since March 13, 2023
Manufacturer reports: 1 unavailable, 1 limited, 1 available

See all current drug shortages

Chemical Identity

CAS7413-34-5

PubChem CID11329481

DTXSIDDTXSID3037123

FormulaC20H20N8Na2O5

Mol. Weight498.4 g/mol

SMILESCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Data Sources

PubChem · compound 11329481Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

methotrexate sodium (CAS 7413-34-5) https://chemicalindependence.com/chemical/7413-34-5/ PubChem: 11329481. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/11329481 FDA National Drug Code directory: CAS 7413-34-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 7413-34-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293359 for CAS 7413-34-5. Reporting year: 2024. https://usatrade.census.gov/