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Trimethoprim

Drug ingredient

CAS 738-70-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 738-70-5
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
56 FDA-registered drug labelers
A-S Medication Solutions
Advanced Rx Pharmacy of Tennessee, LLC
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals of New York LLC
Andhra Organics Limited
ANI Pharmaceuticals, Inc.
ASCLEMED USA INC.
ATLANTIC BIOLOGICALS CORP.
Aurobindo Pharma Limited
AvKARE
AvPAK
Bryant Ranch Prepack
Cardinal Health 107, LLC
Chartwell Governmental & Specialty RX, LLC.
Chartwell RX, LLC
Cronus Pharma LLC
Denton Pharma, Inc. DBA Northwind Pharmaceuticals
Direct_Rx
Dr. Reddy's Labratories Inc.
Golden State Medical Supply, Inc.
Inventaa Industries Private Limited
Ipca Laboratories Limited
Kalchem International inc
Kesin Pharma
LETCO MEDICAL, LLC
Lupin Pharmaceuticals,Inc.
Major Pharmaceuticals
Medisca Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
Northwind Health Company, LLC
Novel Laboratories, Inc.
Novitium Pharma LLC
NuCare Pharmaceuticals, Inc.
PAI Holdings, LLC dba PAI Pharma
PD-Rx Pharmaceuticals, Inc.
Pharmasource Meds, LLC
PharmPak, Inc.
Prasco Laboratories
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
QPharma, Inc.
Quality Care Products LLC
RedPharm Drug, Inc.
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Shouguang Fukang Pharmaceutical Co., Ltd.
Somerset Therapeutics, LLC
Spectrum Laboratory Products, Inc.
Sportpharm LLC
ST. MARY'S MEDICAL PARK PHARMACY
Sun Pharmaceutical Industries, Inc
Teva Parenteral Medicines, Inc.
VERITYRX, LLC
Vista Pharmaceuticals, Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 9 drug and cosmetic product listings (FDA).

  • •Sulfamethoxazole and Trimethoprim
  • •Trimethoprim
  • •Sulfatrim
  • •Sulfamethoxazole and Trimethoprim DS
  • •polymyxin b sulfate and trimethoprim sulfate
  • •Bactrim DS
  • •Sulfamethox-TMP DS
  • •Bactrim
Show all 9
  • •Sulfameth/Trimeth-DS
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.11/gAaron Chemicals LLC
CountryHong Kong
Pack$113.00 / 1 kg
Purity98%
Vendors36 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

35 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.13500 g98%
A2B Chem LLCUnited States$0.20500 g99%
BLD Pharmatech Ltd.China$0.211 kg98%
AA BLOCKSUnited States$0.22500 g99%
BLD Pharmatech Co., LimitedUnited States$0.231 kg98%
Ambeed, Inc.United States$0.231 kg98%
BLD Pharmatech GmbHGermany$0.25500 g98%
Combi-Blocks, Inc.United States$0.251 kg98%
Manchester OrganicsUnited Kingdom$0.35500 g98%
AK Scientific SpecializedUnited States$0.57100 g95%
AstaTech, IncUnited States$0.76250 g97%
AK Scientific, Inc.United States$0.80100 g98%
Apollo Scientific USUnited Kingdom$0.82500 g99.8%
Fulfilled by MolportLatvia$1.005 g—
Angene International LimitedUnited States$1.59100 g98%
Cayman EuropeEstonia$6.7650 g98%
Apexbio Technology LLCUnited States$8.8010 g100%
MedChemExpress MCESweden$9.9210 g99.97%
Life Chemicals Inc.Ukraine → Canada$12.005 g95%
Sigma-Aldrich (Rush Stock)Germany$16.75100 g98%
Sigma-AldrichGermany$16.75100 g98%
InterbioscreenHong Kong$25.5010 g95%
MedKoo Biosciences, IncUnited States$47.5020 g98%
ChemDiv, Inc.United States$60.001 g90%
ChemDiv, Inc. (rush stock)United States$60.001 g—
CliniSciences GmbHSwitzerland$64.501 g99%
MolnovaChina$82.00500 mg99%
TargetMol ChemicalsChina → United States$90.00500 mg99.88%
Vitas M Chemical LimitedHong Kong$144.005 g90%
Labotest KGGermany$453.001000 mg90%
ChemFacesChina$1500.0020 mg98%
AngeneChina → Hong Kong$4266.6730 mg98%
Princeton BioMolecular Research (SC)United States$6500.0020 mg90%
Key Organics Ltd.United Kingdom$6900.0010 mg97%
TimTec, LLCUnited States$9333.3330 mg90%

Chemical Identity

CAS738-70-5
PubChem CID5578
DTXSIDDTXSID3023712
FormulaC14H18N4O3
Mol. Weight290.32 g/mol
SMILESCOC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

Data Sources

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Brief citations

Trimethoprim (CAS 738-70-5) https://chemicalindependence.com/chemical/738-70-5/ PubChem: 5578. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5578 FDA National Drug Code directory: CAS 738-70-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 738-70-5. Reporting year: 2024. https://usatrade.census.gov/