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(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

Drug ingredient

CAS 7365-45-9

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

Molecular structure of 7365-45-9
US productionCBI
Import value, 2024$7.6B
Top sourceIreland 61%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

EPA reports by year
2023
US production Confidential · Imports Confidential
2019
US production Confidential · Imports Confidential

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
EPA-registered manufacturers (3)
Angus Chemical
Avantor
Life Technologies

Why It Matters

Sectors
HealthCore Chemicals
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •15% azelaic acid acne cream
  • •10% azelaic acid acne cream
FDA Shortage Status
No FDA shortage records

Industrial Uses

Used in 1 sector as 2 functional roles.

  • •Catalyst in Pharmaceutical and Medicine ManufacturingUse—non-incorporative activities
  • •Stabilizing agent in Pharmaceutical and Medicine Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.04/gAaron Chemicals LLC
CountryHong Kong
Pack$450.00 / 10 kg
Purity98%
Vendors28 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

27 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.05500 g98%
AA BLOCKSUnited States$0.051 kg98%
A2B Chem LLCUnited States$0.051 kg98%
BLD Pharmatech GmbHGermany$0.061 kg97%
BLD Pharmatech Ltd.China$0.061 kg97%
ChemsceneUnited States$0.071 kg—
Apollo Scientific USUnited Kingdom$0.091 kg99.5%
Fluorochem UKUnited Kingdom$0.111 kg97%
BLD Pharmatech Co., LimitedUnited States$0.111 kg97%
Ambeed, Inc.United States$0.111 kg97%
AK Scientific SpecializedUnited States$0.111 kg98%
Fluorochem EUGermany$0.13500 g97%
Angene International LimitedUnited States$0.14250 g98%
AK Scientific, Inc.United States$0.151 kg99%
Combi-Blocks, Inc.United States$0.251 kg97%
Sigma-Aldrich (Rush Stock)Germany$0.2950 kg99.5%
Sigma-AldrichGermany$0.2950 kg99.5%
AstaTech, IncUnited States$0.75100 g95%
Apexbio Technology LLCUnited States$0.96250 g98%
MedKoo Biosciences, IncUnited States$10.0025 g98%
TargetMol ChemicalsChina → United States$40.002 g99.93%
TargetMol Chemicals EUAustria$56.001 g99.93%
MolnovaChina$74.00500 mg99%
MedChemExpress MCESweden$87.121 g99.94%
Labotest KGGermany$217.805000 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%
ChemDiv, Inc.United States$5480.0050 mg90%

Chemical Identity

CAS7365-45-9
PubChem CID23831
DTXSIDDTXSID5040382
FormulaC8H18N2O4S
Mol. Weight238.31 g/mol
SMILESC1CN(CCN1CCO)CCS(=O)(=O)O

Data Sources

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Brief citations

(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid (CAS 7365-45-9) https://chemicalindependence.com/chemical/7365-45-9/ EPA CompTox (DSSTox): DTXSID5040382. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5040382 PubChem: 23831. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/23831 EPA Chemical Data Reporting: 7365-45-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 7365-45-9. Reporting year: 2024. https://usatrade.census.gov/