Apraclonidine hydrochloride

Drug ingredient

CAS 73218-79-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 73218-79-8 — 1 HCl

US productionNot reported

Import value, 2024$114M

Top sourceChina 26%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy

Australia
Brazil
Czech Republic
Ireland
Sweden
Ukraine
Poland
United Arab Emirates
Hungary
Israel
Netherlands
Canada
Saudi Arabia
Greece
Belgium
Austria
Latvia
Singapore
Denmark

4 FDA-registered drug labelers

CARBOGEN AMCIS AG

Harrow Eye, LLC

PCAS Finland Oy

Sandoz Inc

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Iopidine 1%
•Apraclonidine

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1240.00/gTargetMol Chemicals

CountryChina (registered: United States)

Pack$248.00 / 200 mg

Purity99.74%

Vendors13 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

12 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$2296.00	250 mg	98%
Aaron Chemicals LLC	Hong Kong	$2912.00	250 mg	97%
Angene Chemical	China → Hong Kong	$2932.00	250 mg	97%
AA BLOCKS	United States	$3008.00	250 mg	98%
Angene International Limited	United States	$6200.00	25 mg	98%
Ambeed, Inc.	United States	$13000.00	1 mg	95%
MedChemExpress MCE	Sweden	$13503.60	25 mg	98.96%
MedKoo Biosciences, Inc	United States	$14000.00	25 mg	98%
Cayman Europe	Estonia	$22134.00	10 mg	98%
TimTec, LLC	United States	$90000.00	2 mg	90%
Sigma-Aldrich (Rush Stock)	Germany	$110180.00	1 mg	—
Sigma-Aldrich	Germany	$110180.00	1 mg	—

Chemical Identity

CAS73218-79-8

PubChem CID51763

DTXSIDDTXSID6045749

FormulaC9H11Cl3N4

Mol. Weight281.6 g/mol

SMILESC1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl.Cl

Data Sources

PubChem · compound 51763Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Apraclonidine hydrochloride (CAS 73218-79-8) https://chemicalindependence.com/chemical/73218-79-8/ PubChem: 51763. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/51763 FDA National Drug Code directory: CAS 73218-79-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 73218-79-8. Reporting year: 2024. https://usatrade.census.gov/