Melatonin

Drug ingredient

CAS 73-31-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 73-31-4
US productionNot reported
Import value, 2024$174M
Top sourceItaly 69%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293790 · basket

These shares come from HS customs code 293790, which covers 10 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 69%ItalyCN 22%ChinaDE 3%GermanyIN 2%IndiaJP 2%Japan
17 FDA-registered drug labelers
BioActive Nutritional, Inc.
Deseret Biologicals
Deseret Biologicals, Inc.
Dr. Donna Restivo DC
Energique, Inc.
Flamma S.p.A.
Guna spa
Huanggang Saikang Pharmaceutical Co., Ltd.
Liddell Laboratories, Inc.
Medisca Inc.
Nutritional Specialties, Inc.
Pain & Stress Center Products
Pro Weight Loss Inc.
Professional Complementary Health Formulas
Professional Compounding Centers of America
Swati Spentose Private Limited
Willow Birch Pharma, LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 40 drug and cosmetic product listings (FDA).

  • •GUNA-FLAM
  • •Perfect Sleep
  • •Vascuflow
  • •Melatonin Pro
  • •Young Again
  • •ANTI AGE Stress
  • •GUNA-MALE
  • •GUNA-Prostate
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.32/gAaron Chemicals LLC
CountryHong Kong
Pack$159.00 / 500 g
Purity98%
Vendors39 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS73-31-4
PubChem CID896
DTXSIDDTXSID1022421
FormulaC13H16N2O2
Mol. Weight232.28 g/mol
SMILESCC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

Data Sources

Brief citations

Melatonin (CAS 73-31-4) https://chemicalindependence.com/chemical/73-31-4/ PubChem: 896. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/896 FDA National Drug Code directory: CAS 73-31-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293790 for CAS 73-31-4. Reporting year: 2024. https://usatrade.census.gov/