Hydromorphone hydrochloride

Drug ingredientActive Shortage

CAS 71-68-1

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$103M

Top sourceAustralia 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293911 · basket

These shares come from HS customs code 293911, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

AU 31%AustraliaGB 27%United KingdomCZ 19%Czech RepublicDE 14%GermanyES 5%Spain

Taiwan
New Zealand

29 FDA-registered drug labelers

American Health Packaging

Ascent Pharmaceuticals Inc

ASCLEMED USA INC.

Aurolife Pharma, LLC

Bond Pharmacy INC

Bryant Ranch Prepack

Camber Pharmaceuticals, Inc.

Cambrex Charles City, Inc

Chattem Chemicals, Inc.

Fagron Inc

Fresenius Kabi USA, LLC

Hikma Pharmaceuticals USA Inc.

Hospira, Inc.

Janssen Pharmaceutical Sciences Unlimited

LETCO MEDICAL, LLC

Medisca Inc.

Noramco, LLC

Padagis US LLC

Pharma Source Direct, Inc.

Professional Compounding Centers of America

Purisys LLC

Rhodes Pharmaceuticals L.P.

Siegfried USA, LLC

SpecGx LLC

Spectrum Laboratory Products, Inc.

Teva Parenteral Medicines, Inc.

Trigen Laboratories, LLC

Veranova, L.P.

XLCare Pharmaceuticals, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Hydromorphone Hydrochloride
•Dilaudid

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Hydromorphone Hydrochloride Injection
Shortage listed since October 31, 2017
Manufacturer reports: 2 unavailable, 2 limited, 3 available

See all current drug shortages

Chemical Identity

CAS71-68-1

PubChem CID5462347

DTXSIDDTXSID90991291

FormulaC17H20ClNO3

Mol. Weight321.8 g/mol

SMILESCN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4.Cl

Data Sources

PubChem · compound 5462347Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Hydromorphone hydrochloride (CAS 71-68-1) https://chemicalindependence.com/chemical/71-68-1/ PubChem: 5462347. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5462347 FDA National Drug Code directory: CAS 71-68-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 71-68-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293911 for CAS 71-68-1. Reporting year: 2024. https://usatrade.census.gov/