D-Mannitol

Drug ingredient

CAS 69-65-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US production1.5M lb

Import value, 2024$46M

Import volumeZero

Import dependency0%

Top sourceItaly 78%

Production is reported production, not a complete census of factories. Production reporting year: 2023.

Where It Comes From

Customs basis: HS 290543 · exact

EPA reports by year

2023: US production 1.5M lb · Imports Zero
2019: US production Confidential · Imports Confidential

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 78%ItalyCN 18%ChinaDE 2%GermanyIN 2%India

Japan
Australia

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Roquette America

Why It Matters

Sectors

Core ChemicalsHealth

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Mannitol
•Osmitrol
•QR PAIN
•Sorbitol-Mannitol

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Laboratory chemicals in All Other Chemical Product and Preparation ManufacturingProcessing—repackaging

Vendor Pricing

$0.50/gA2B Chem LLC

CountryUnited States

Pack$50.00 / 100 g

Purity95%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
Combi-Blocks, Inc.	United States	$0.50	100 g	95%
AA BLOCKS	United States	$0.63	100 g	95%
Aaron Chemicals LLC	Hong Kong	$70.64	25 g	50%
Angene Chemical	China → Hong Kong	$71.00	25 g	50%
Angene International Limited	United States	$96.80	5 g	98%
Chengdu Biopurify Phytochemicals Ltd.	China	$142.00	1 g	98%
Labotest KG	Germany	$217.80	5000 mg	90%
ChemFaces	China	$1500.00	20 mg	98%
Vitas M Chemical Limited	Hong Kong	$3170.00	100 mg	90%
TimTec, LLC (back-ordered)	United States	$32000.00	15 mg	94%

Chemical Identity

CAS69-65-8

PubChem CID6251

DTXSIDDTXSID1023235

FormulaC6H14O6

Mol. Weight182.17 g/mol

SMILESC(C(C(C(C(CO)O)O)O)O)O

Data Sources

EPA CompTox (DSSTox) · DTXSID1023235Retrieved 2026-04-06
PubChem · compound 6251Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Core Chemicals

Brief citations

D-Mannitol (CAS 69-65-8) https://chemicalindependence.com/chemical/69-65-8/ EPA CompTox (DSSTox): DTXSID1023235. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023235 PubChem: 6251. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6251 EPA Chemical Data Reporting: 69-65-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 69-65-8. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290543 for CAS 69-65-8. Reporting year: 2024. https://usatrade.census.gov/