caffeine citrate

Drug ingredient

CAS 69-22-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$106M

Top sourceChina 46%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293930 · narrow

These shares come from HS customs code 293930, which covers 2 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 46%ChinaDE 28%GermanyIN 14%IndiaIT 7%ItalyGB 2%United Kingdom

Austria
Japan
Israel
Belgium
Sweden
Spain
Indonesia
Switzerland

9 FDA-registered drug labelers

Armas Pharmaceuticals Inc.

Eugia US LLC

Exela Pharma Sciences, LLC

Fresenius Kabi USA, LLC

Green Earth Health Inc.

Hikma Pharmaceuticals USA Inc.

Micro Labs Limited

Sagent Pharmaceuticals

Sun Pharmaceutical Industries, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•caffeine citrate
•PAIN Relief Caffeine AND HEMP
•Caffeine Citrate Oral Solution
•Cafcit

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS69-22-7

PubChem CID6241

DTXSIDDTXSID5046938

FormulaC14H18N4O9

Mol. Weight386.31 g/mol

SMILESCN1C=NC2=C1C(=O)N(C(=O)N2C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Data Sources

PubChem · compound 6241Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

caffeine citrate (CAS 69-22-7) https://chemicalindependence.com/chemical/69-22-7/ PubChem: 6241. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6241 FDA National Drug Code directory: CAS 69-22-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293930 for CAS 69-22-7. Reporting year: 2024. https://usatrade.census.gov/