Trisodium citrate

Drug ingredient

CAS 68-04-2

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$130M

Top sourceIsrael 39%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291815 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291815, which covers 34 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IL 39%IsraelIN 14%IndiaDE 13%GermanyCN 10%ChinaIT 6%Italy

Brazil
Japan
Netherlands
Australia
Lithuania
United Kingdom
Norway
South Korea
Czech Republic
Lebanon
Ireland
Turkey
Estonia
Mexico
Switzerland

EPA-registered manufacturers (6)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Cargill, Incorporated

Ecolab

Hawkins

Hydrite Chemical

P&G

Show all 6

Pvs Chemicals

Domestic parents -- activity not disclosed (4)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Ambyth Chemical

Niche Chem Industries

Valudor Products

Wilbur-Ellis Holdings Ii

EPA-registered importers (8)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Jungbunzlauer Suisse Ag · CH Switzerland

Reckitt Benckiser Group · GB United Kingdom

Colgate-Palmolive

Jungbunzlauer

Reckitt Benckiser

Show all 8

S.C. Johnson & Son

Solenis

Target

Why It Matters

Sectors

HealthFoodMetals & MiningConsumer Products

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Lipotox

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 3 functional roles.

•Cleaning agent in Miscellaneous Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•pH regulating agent in Food, beverage, and tobacco product manufacturing (100%)Use—non-incorporative activities
•Chelating agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Cleaning agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS68-04-2

PubChem CID6224

DTXSIDDTXSID2026363

FormulaC6H5Na3O7

Mol. Weight258.07 g/mol

SMILESC(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+]

Data Sources

EPA CompTox (DSSTox) · DTXSID2026363Retrieved 2026-04-06
PubChem · compound 6224Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Trisodium citrate (CAS 68-04-2) https://chemicalindependence.com/chemical/68-04-2/ EPA CompTox (DSSTox): DTXSID2026363. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID2026363 PubChem: 6224. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6224 EPA Chemical Data Reporting: 68-04-2. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 68-04-2. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291815 for CAS 68-04-2. Reporting year: 2024. https://usatrade.census.gov/