Avatrombopag maleate

Drug ingredient

CAS 677007-74-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$447M

Top sourceChina 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293410 · basket

These shares come from HS customs code 293410, which covers 83 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 31%ChinaDE 25%GermanyMX 19%MexicoJP 13%JapanIN 5%India

United Kingdom
Italy
Ukraine
Spain
Netherlands
Poland
Belgium
Canada
Croatia
Bulgaria
Taiwan
Sweden
Slovakia
Slovenia

9 FDA-registered drug labelers

AkaRx, Inc.

APICHEM Laboratories Private Limited

Eisai Manufacturing Ltd

Granules India Limited

HONOUR LAB LIMITED

NURAY CHEMICALS PRIVATE LIMITED

Sterling Pharma Solutions Limited

STHREE CHEMICALS PRIVATE LIMITED

Zhejiang Ausun Pharmaceutical Co., Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Doptelet
•Doptelet Sprinkle

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS677007-74-8

PubChem CID9918581

DTXSIDDTXSID001027855

FormulaC33H38Cl2N6O7S2

Mol. Weight765.7 g/mol

SMILESC1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl.C(=CC(=O)O)C(=O)O

Data Sources

PubChem · compound 9918581Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Avatrombopag maleate (CAS 677007-74-8) https://chemicalindependence.com/chemical/677007-74-8/ PubChem: 9918581. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9918581 FDA National Drug Code directory: CAS 677007-74-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293410 for CAS 677007-74-8. Reporting year: 2024. https://usatrade.census.gov/