Diketene

CAS 674-82-8

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$286M

Top sourceChina 48%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293220 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 293220, which covers 151 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 48%ChinaIN 15%IndiaJP 7%JapanGB 7%United KingdomCH 7%Switzerland

Mexico
Austria
Indonesia
Czech Republic
Slovakia
Malaysia
Israel
Poland
Vietnam
Ukraine
South Africa
Singapore
Russia
Lithuania
Hungary
Belarus
Brazil
Australia

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Eastman Chemical

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in All Other Basic Organic Chemical ManufacturingProcessing as a reactant

Vendor Pricing

$101.00/gA2B Chem LLC (1 week)

CountryUnited States

Pack$505.00 / 5 g

Purity95%

Vendors3 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

2 more vendors

Vendor	Country	$/g	Pack	Purity
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%

Chemical Identity

CAS674-82-8

PubChem CID12661

DTXSIDDTXSID9027289

FormulaC4H4O2

Mol. Weight84.07 g/mol

SMILESC=C1CC(=O)O1

Data Sources

EPA CompTox (DSSTox) · DTXSID9027289Retrieved 2026-04-06
PubChem · compound 12661Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Diketene (CAS 674-82-8) https://chemicalindependence.com/chemical/674-82-8/ EPA CompTox (DSSTox): DTXSID9027289. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027289 PubChem: 12661. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/12661 EPA Chemical Data Reporting: 674-82-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 674-82-8. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 293220 for CAS 674-82-8. Reporting year: 2024. https://usatrade.census.gov/